Macrophage Activation

• Author : Khalid Hussain Bhat
• Publisher : BoD – Books on Demand
• Release Date : 2020-03-25
• ISBN : 9781789846447

Macrophages are the sentinels of the immune system whose role has evolved beyond providing aseptic conditions to homeostasis, immune regulation, development, and behaviour. These cells have varied ontogenetic origins which reflects in their phenotypic and functional heterogeneity. Macrophage functions are fine-tuned by exogenous and endogenous signals and once tweaked, the information is included in their genetic makeup, albeit not indefinitely. Subversion of the macrophage functions is the hallmark of many pathogenic organisms and modulation of macrophage activity is pivotal to

• Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
• Publisher : Garland Science
• Release Date : 2010-06-22
• ISBN : 0815344570

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

• Author : Marianna Bei,Basak E. Uygun
• Publisher : Frontiers Media SA
• Release Date : 2019-11-01
• ISBN : 9782889631070

Skin is the largest organ of the body and is necessary for survival, since it performs many functions such as providing a physical barrier to the external environment, sensation, retention of normal hydration and thermal regulation. Significant skin loss is associated with high mortality and morbidity in the acute phase, and with physically and cosmetically drastic scarring in the long term. Although there are a number of tissue-engineered products in the clinic that are used as skin substitutes to promote

• Author : David S. Nelson
• Publisher : Academic Press
• Release Date : 2014-06-28
• ISBN : 9781483274775

Immunobiology of the Macrophage presents an account of the state of knowledge of the immunobiology of the macrophage. The book’s contributors—immunologists of diverse scientific and geographic backgrounds—have been encouraged to give personal accounts of developments in their special fields of interest as well as critical surveys of the backgrounds leading to these developments. The book begins with a study on the functions of macrophages in the initiation and regulation of antibody responses in vitro. This is followed

• Author : Heiko Mühl,Patrizia Rovere-Querini,Amiram Ariel,Jerrold S. Levine,Isabelle Maridonneau-Parini
• Publisher : Frontiers E-books
• Release Date : 2022-08-15
• ISBN : 9782889190737

Macrophages were initially identified as a key element in the innate host response to infection and injury due to their phagocytic clearance and elimination of pathogenic and non-pathogenic entities. However, as macrophage research advanced it became clear that not only are these cells amenable to the acquisition of multiple plastic phenotypes during inflammatory responses to different pathogens, they also play a paramount role in the termination of inflammation and acquired immune responses. In addition, macrophages profoundly affect host physiology when

• Author : Adriano Rossi,Deborah A. Sawatzky
• Publisher : Springer Science & Business Media
• Release Date : 2008-03-17
• ISBN : 9783764375065

This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

• Author : Jae Youl Cho
• Publisher : Academic Press
• Release Date : 2022-03-18
• ISBN : 9780128223697

In recent years, researchers around the globe have deep dived into the fascination world of the Macrophage and its diverse role in tissue development, angiogenesis, and wound healing, and above all the untapped mystery of the wondering immune system within our body. Macrophages and their role in inflammation includes all the latest information of macrophages and inflammation as well as it provides an in-depth understanding of this complex and rapidly progressing field of study. Outlines the role of macrophages in

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2018-11-24
• ISBN : 9780128138335

Translational Inflammation links laboratory and clinical data within primary and secondary care to clinical research data and offers a holistic and innovative approach to chronic inflammation and ageing. Understanding the role of inflammation as a part of clinical disease states is becoming a valuable tool in both direct treatment and the development of therapeutics. Translational Inflammation, the 4th volume in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. Emphasizes

• Author : Tarcio Teodoro Braga,Ivan C. Moura,Ana Paula Lepique,Niels Olsen Saraiva Camara
• Publisher : Frontiers Media SA
• Release Date : 2017-10-13
• ISBN : 9782889453320

Macrophages comprehend a heterogeneous mononuclear phagocytic population with wide range phenotypes and roles in homeostasis maintenance and diseases, such as infections, autoimmunity and cancer. Technology improvements enable researchers to track different macrophage populations in different tissues and situations and hypothesize on their role in promoting inflammation or stimulating tissue repair. Through innate immune recognition system macrophages can launch several effector artilleries that culminate in the production of various types of inflammatory mediators as cytokines, chemokines, lipid mediators and oxygen reactive

• Author : Geanncarlo Lugo-Villarino,Céline Cougoule,Etienne Meunier,Yoann Rombouts,Christel Vérollet,Luciana Balboa
• Publisher : Frontiers Media SA
• Release Date : 2019-10-04
• ISBN : 9782889630578

The Mononuclear Phagocyte System (MPS) of vertebrates is composed of monocytes, macrophages and dendritic cells. Together, they form part of the first line of immune defense against a variety of pathogens (bacteria, fungi, parasites and viruses), and thus play an important role in maintaining organism homeostasis. The mode of transmission, type of replication and mechanism of disease-causing differ significantly for each pathogen, eliciting a unique immune response in the host. Within this context, the MPS acts as both the sentinel

• Author : Tamas Fulop,Claudio Franceschi,Katsuiki Hirokawa,Graham Pawelec
• Publisher : Springer Science & Business Media
• Release Date : 2009-02-27
• ISBN : 9781402090639

This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.

• Author : Bruce Alberts
• Publisher : Unknown
• Release Date : 2004
• ISBN : 0815332181

• Author : Bruna Corradetti
• Publisher : Springer
• Release Date : 2016-11-30
• ISBN : 9783319454337

This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development

• Author : Subhra K. Biswas,Alberto Mantovani
• Publisher : Springer
• Release Date : 2014-11-12
• ISBN : 9781493913114

Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to

• Author : Tamás Röszer
• Publisher : Springer Nature
• Release Date : 2020-08-03
• ISBN : 9783030504809

Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of