Innovative Approaches in Drug Discovery

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  • Publisher : Academic Press
  • Release : 03 October 2016
  • ISBN : 9780128018224
  • Page : 480 pages
  • Rating : 4.5/5 from 103 voters

Innovative Approaches in Drug Discovery Book PDF summary

Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences. Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery

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Innovative Approaches in Drug Discovery

Innovative Approaches in Drug Discovery
  • Author : Bhushan Patwardhan,Rathnam Chaguturu
  • Publisher : Academic Press
  • Release Date : 2016-10-03
  • ISBN : 9780128018224
DOWNLOAD BOOKInnovative Approaches in Drug Discovery

Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches.

New Approaches to Drug Discovery

New Approaches to Drug Discovery
  • Author : Ulrich Nielsch,Ulrike Fuhrmann,Stefan Jaroch
  • Publisher : Springer
  • Release Date : 2016-04-08
  • ISBN : 3319289128
DOWNLOAD BOOKNew Approaches to Drug Discovery

This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technologies to identify new

Innovative Methods for Rare Disease Drug Development

Innovative Methods for Rare Disease Drug Development
  • Author : Shein-Chung Chow
  • Publisher : CRC Press
  • Release Date : 2020-11-11
  • ISBN : 9781000208337
DOWNLOAD BOOKInnovative Methods for Rare Disease Drug Development

In the United States, a rare disease is defined by the Orphan Drug Act as a disorder or condition that affects fewer than 200,000 persons. For the approval of "orphan" drug products for rare diseases, the traditional approach of power analysis for sample size calculation is not feasible because there are only limited number of subjects available for clinical trials. In this case, innovative approaches are needed for providing substantial evidence meeting the same standards for statistical assurance as drugs used

Drug Discovery and Development, Volume 1

Drug Discovery and Development, Volume 1
  • Author : Mukund S. Chorghade
  • Publisher : Wiley-Interscience
  • Release Date : 2006-06-16
  • ISBN : 0471398489
DOWNLOAD BOOKDrug Discovery and Development, Volume 1

From first principles to real-world applications -- here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines--from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume resource provides

Innovative Approaches in Drug Research

Innovative Approaches in Drug Research
  • Author : A. F. Harms
  • Publisher : Elsevier Publishing Company
  • Release Date : 1986
  • ISBN : UOM:39015011452201
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New Approaches to Drug Discovery

New Approaches to Drug Discovery
  • Author : Ulrich Nielsch,Ulrike Fuhrmann,Stefan Jaroch
  • Publisher : Springer
  • Release Date : 2016-03-30
  • ISBN : 9783319289144
DOWNLOAD BOOKNew Approaches to Drug Discovery

This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technologies to identify new

New Approaches to Drug Development

New Approaches to Drug Development
  • Author : Pierre Jollès
  • Publisher : Unknown
  • Release Date : 1989
  • ISBN : 0817661298
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Modern CNS Drug Discovery

Modern CNS Drug Discovery
  • Author : Rudy Schreiber
  • Publisher : Springer Nature
  • Release Date : 2021-06-17
  • ISBN : 9783030623517
DOWNLOAD BOOKModern CNS Drug Discovery

This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the

Drug Repurposing

Drug Repurposing
  • Author : Farid A. Badria
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-12-02
  • ISBN : 9781839685200
DOWNLOAD BOOKDrug Repurposing

Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
  • Publisher : National Academies Press
  • Release Date : 2014-02-06
  • ISBN : 9780309292498
DOWNLOAD BOOKImproving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective

Molecular Evolutionary Models in Drug Discovery

Molecular Evolutionary Models in Drug Discovery
  • Author : Juan Bueno
  • Publisher : Academic Press
  • Release Date : 2020-01-22
  • ISBN : 9780128189290
DOWNLOAD BOOKMolecular Evolutionary Models in Drug Discovery

Molecular Evolutionary Models in Drug Discovery explores the application of evolutionary molecular models in drug discovery in which secondary metabolites play a fundamental role. Secondary metabolites are not produced in isolation, they are the result of the interaction of genes, metabolism and the environment. The book examines the role of secondary metabolites as leads in drug discovery and on the development of a rational bioprospecting model for new medicines based on the evolution of secondary metabolism. These evolutionary models are

Drug Discovery Targeting Drug-Resistant Bacteria

Drug Discovery Targeting Drug-Resistant Bacteria
  • Author : Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta
  • Publisher : Academic Press
  • Release Date : 2020-05-15
  • ISBN : 9780128184813
DOWNLOAD BOOKDrug Discovery Targeting Drug-Resistant Bacteria

Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules

Innovative Strategies, Statistical Solutions and Simulations for Modern Clinical Trials

Innovative Strategies, Statistical Solutions and Simulations for Modern Clinical Trials
  • Author : Mark Chang,John Balser,Jim Roach,Robin Bliss
  • Publisher : CRC Press
  • Release Date : 2019-03-29
  • ISBN : 9781351214520
DOWNLOAD BOOKInnovative Strategies, Statistical Solutions and Simulations for Modern Clinical Trials

"This is truly an outstanding book. [It] brings together all of the latest research in clinical trials methodology and how it can be applied to drug development.... Chang et al provide applications to industry-supported trials. This will allow statisticians in the industry community to take these methods seriously." Jay Herson, Johns Hopkins University The pharmaceutical industry's approach to drug discovery and development has rapidly transformed in the last decade from the more traditional Research and Development (R & D) approach to

Phenotypic Drug Discovery

Phenotypic Drug Discovery
  • Author : Angelique Augustin,Beverley Isherwood
  • Publisher : Royal Society of Chemistry
  • Release Date : 2020-12-10
  • ISBN : 9781788018760
DOWNLOAD BOOKPhenotypic Drug Discovery

Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and

Lead Generation Approaches in Drug Discovery

Lead Generation Approaches in Drug Discovery
  • Author : Zoran Rankovic,Richard Morphy
  • Publisher : John Wiley & Sons
  • Release Date : 2010-04-07
  • ISBN : 0470584165
DOWNLOAD BOOKLead Generation Approaches in Drug Discovery

An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory,