Trace Amines and Neurological Disorders

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  • Publisher : Academic Press
  • Release : 12 July 2016
  • ISBN : 9780128036167
  • Page : 432 pages
  • Rating : 4.5/5 from 103 voters

Trace Amines and Neurological Disorders Book PDF summary

Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders. Focuses on recent findings on trace amines, providing insights into the functional significance, molecular mechanisms, and biological relevance of TAARS in neurological disorders Edited work with chapters authored by leaders in the field from around the globe, the broadest, most expert coverage available Provides cutting-edge research on trace amines-mediated signaling in vertebrate model systems

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Trace Amines and Neurological Disorders

Trace Amines and Neurological Disorders
  • Author : Tahira Farooqui,Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2016-07-12
  • ISBN : 9780128036167
DOWNLOAD BOOKTrace Amines and Neurological Disorders

Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is

Neuropsychopharmacology of the Trace Amines

Neuropsychopharmacology of the Trace Amines
  • Author : Alan A. Boulton,Peter R. Bieck,L. Maitre,P. Riederer
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • ISBN : 9781461250104
DOWNLOAD BOOKNeuropsychopharmacology of the Trace Amines

A probable neurobiological role for the trace amines began to emerge as soon as techniques sufficiently sophisticated to detect them were developed. Techniques for quantitative analyses included radioenzymatic procedures and, more recently, HPlC-EC and auto mated GC-MS. The methods are applied after separation of the sub stances to be analyzed and after their purification by physicochemical procedures that are becoming more and more efficient. The identification and quantitative analysis of minute amounts of trace amines in biological fluids or tissues

Biogenic Amines on Food Safety

Biogenic Amines on Food Safety
  • Author : Claudia Ruiz-Capillas,Ana Herrero Herranz
  • Publisher : MDPI
  • Release Date : 2019-07-16
  • ISBN : 9783039210541
DOWNLOAD BOOKBiogenic Amines on Food Safety

Biogenic amines have been known for some time. These compounds are found in varying concentrations in a wide range of foods (fish, cheese, meat, wine, beer, vegetables, etc.) and their formations are influenced by different factors associated to those foods (composition, additives, ingredients, storage, microorganism, packaging, handing, conservation, etc.). The intake of foods containing high concentrations of biogenic amines can present a health hazard. Additionally, they have been used to establish indexes in various foods in order to signal the

Diet and Health

Diet and Health
  • Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Diet and Health
  • Publisher : National Academies Press
  • Release Date : 1989-01-01
  • ISBN : 9780309039949
DOWNLOAD BOOKDiet and Health

Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.

The Combinatorial Index

The Combinatorial Index
  • Author : Barry A. Bunin
  • Publisher : Elsevier
  • Release Date : 1998-04-15
  • ISBN : 0080542409
DOWNLOAD BOOKThe Combinatorial Index

With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which

Magnesium in the Central Nervous System

Magnesium in the Central Nervous System
  • Author : Robert Vink,Mihai Nechifor
  • Publisher : University of Adelaide Press
  • Release Date : 2011
  • ISBN : 9780987073051
DOWNLOAD BOOKMagnesium in the Central Nervous System

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the

Public Health Consequences of E-Cigarettes

Public Health Consequences of E-Cigarettes
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on the Review of the Health Effects of Electronic Nicotine Delivery Systems
  • Publisher : National Academies Press
  • Release Date : 2018-05-18
  • ISBN : 9780309468374
DOWNLOAD BOOKPublic Health Consequences of E-Cigarettes

Millions of Americans use e-cigarettes. Despite their popularity, little is known about their health effects. Some suggest that e-cigarettes likely confer lower risk compared to combustible tobacco cigarettes, because they do not expose users to toxicants produced through combustion. Proponents of e-cigarette use also tout the potential benefits of e-cigarettes as devices that could help combustible tobacco cigarette smokers to quit and thereby reduce tobacco-related health risks. Others are concerned about the exposure to potentially toxic substances contained in e-cigarette

Rewire Your Brain

Rewire Your Brain
  • Author : John B. Arden, PhD
  • Publisher : John Wiley & Sons
  • Release Date : 2010-03-22
  • ISBN : 9780470487297
DOWNLOAD BOOKRewire Your Brain

How to rewire your brain to improve virtually every aspect of your life-based on the latest research in neuroscience and psychology on neuroplasticity and evidence-based practices Not long ago, it was thought that the brain you were born with was the brain you would die with, and that the brain cells you had at birth were the most you would ever possess. Your brain was thought to be “hardwired” to function in predetermined ways. It turns out that's not true.

Progressive Brain Disorders in Childhood

Progressive Brain Disorders in Childhood
  • Author : Juan M. Pascual
  • Publisher : Cambridge University Press
  • Release Date : 2017-04-20
  • ISBN : 9781107042056
DOWNLOAD BOOKProgressive Brain Disorders in Childhood

A review of childhood neurodegenerative and other progressive but non-degenerative disorders to guide their diagnosis and management.

Neurotransmitters, Drugs and Brain Function

Neurotransmitters, Drugs and Brain Function
  • Author : Roy Webster
  • Publisher : John Wiley & Sons
  • Release Date : 2001-11-28
  • ISBN : 0471978191
DOWNLOAD BOOKNeurotransmitters, Drugs and Brain Function

Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions. It offers a working explanation of drug and

Fluoride in Drinking Water

Fluoride in Drinking Water
  • Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Fluoride in Drinking Water
  • Publisher : National Academies Press
  • Release Date : 2007-01-22
  • ISBN : 9780309101288
DOWNLOAD BOOKFluoride in Drinking Water

Most people associate fluoride with the practice of intentionally adding fluoride to public drinking water supplies for the prevention of tooth decay. However, fluoride can also enter public water systems from natural sources, including runoff from the weathering of fluoride-containing rocks and soils and leaching from soil into groundwater. Fluoride pollution from various industrial emissions can also contaminate water supplies. In a few areas of the United States fluoride concentrations in water are much higher than normal, mostly from natural

Neuropharmacology of New Psychoactive Substances (NPS)

Neuropharmacology of New Psychoactive Substances (NPS)
  • Author : Michael H. Baumann,Richard A. Glennon,Jenny L. Wiley
  • Publisher : Springer
  • Release Date : 2017-04-13
  • ISBN : 9783319524443
DOWNLOAD BOOKNeuropharmacology of New Psychoactive Substances (NPS)

Designer drugs, or new psychoactive substances (NPS), are synthetic chemicals that mimic the effects of classic drugs of abuse. There has been an alarming worldwide increase in the abuse of NPS in recent years. NPS are cheap, easy to obtain, and often legally available. In this volume, leading experts summarize the latest studies regarding the molecular mechanisms of action, behavioral effects, and adverse consequences of popular NPS. Specific chapters clarify the differences between various types of NPS, namely: stimulants, cannabinoids

Toxicological Profile for Polycyclic Aromatic Hydrocarbons

Toxicological Profile for Polycyclic Aromatic Hydrocarbons
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1995
  • ISBN : UOM:39015038438415
DOWNLOAD BOOKToxicological Profile for Polycyclic Aromatic Hydrocarbons

Neuropathology of Drug Addictions and Substance Misuse Volume 2

Neuropathology of Drug Addictions and Substance Misuse Volume 2
  • Author : Victor R. Preedy
  • Publisher : Academic Press
  • Release Date : 2016-03-25
  • ISBN : 9780128003756
DOWNLOAD BOOKNeuropathology of Drug Addictions and Substance Misuse Volume 2

Neuropathology of Drug Addictions and Substance Misuse, Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects is the second of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader’s knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 2 addresses stimulants, club and dissociative drugs, hallucinogens, and inhalants

High Calorie Diet and the Human Brain

High Calorie Diet and the Human Brain
  • Author : Akhlaq A. Farooqui
  • Publisher : Springer
  • Release Date : 2015-03-25
  • ISBN : 9783319152547
DOWNLOAD BOOKHigh Calorie Diet and the Human Brain

The purpose of this monograph is to present readers with a comprehensive and cutting edge description of neurochemical effects of diet (beneficial and harmful effects) in normal human brain and to discuss how present day diet promotes pathogenesis of stroke, AD, PD, and depression in a manner that is useful not only to students and teachers but also to researchers, dietitians, nutritionists and physicians. A diet in sufficient amount and appropriate macronutrients is essential for optimal health of human body