The Human Mitochondrial Genome

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  • Publisher : Academic Press
  • Release : 23 July 2020
  • ISBN : 9780128226421
  • Page : 596 pages
  • Rating : 4.5/5 from 103 voters

The Human Mitochondrial Genome Book PDF summary

The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways. Fully examines recent advances and technological innovations in the field, enabling new mtDNA studies, variant and mutation identification, pathogenic assessment, and therapies Disease discussion accompanied by diagnostic and therapeutic strategies currently implemented clinically Outlines and discusses essential research protocols and perspectives for young scientists to pick up Features an international team of authoritative contributors from basic biologists to clinician-scientists

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The Human Mitochondrial Genome

The Human Mitochondrial Genome
  • Author : Giuseppe Gasparre,Anna Maria Porcelli
  • Publisher : Academic Press
  • Release Date : 2020-07-23
  • ISBN : 9780128226421
DOWNLOAD BOOKThe Human Mitochondrial Genome

The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including

Human Mitochondrial DNA and the Evolution of Homo sapiens

Human Mitochondrial DNA and the Evolution of Homo sapiens
  • Author : Hans-Jürgen Bandelt,Martin Richards,Vincent Macaulay
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-09-05
  • ISBN : 9783540317890
DOWNLOAD BOOKHuman Mitochondrial DNA and the Evolution of Homo sapiens

Mitochondrial DNA is one of the most closely explored genetic systems, because it can tell us so much about the human past. This book takes a unique perspective, presenting the disparate strands that must be tied together to exploit this system. From molecular biology to anthropology, statistics to ancient DNA, this first volume of three presents a comprehensive global picture and a critical appraisal of human mitochondrial DNA variation.

The Human Mitochondrial Genome

The Human Mitochondrial Genome
  • Author : Giuseppe Gasparre,Anna Maria Porcelli
  • Publisher : Academic Press
  • Release Date : 2020-08-19
  • ISBN : 9780128196564
DOWNLOAD BOOKThe Human Mitochondrial Genome

The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including

The Evolution of Human Mitochondrial DNA

The Evolution of Human Mitochondrial DNA
  • Author : Rebecca Louise Cann
  • Publisher : Unknown
  • Release Date : 1982
  • ISBN : UCAL:C2935263
DOWNLOAD BOOKThe Evolution of Human Mitochondrial DNA

Mitochondrial DNA

Mitochondrial DNA
  • Author : Herve Seligmann,Ganesh Warthi
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-10-31
  • ISBN : 9781789842654
DOWNLOAD BOOKMitochondrial DNA

The very short genomes of mitochondria summarize the complexity of molecular biology and its interactions with cellular and whole organism biology. Studies of mitogenomes contribute to the understanding of molecular biology and evolution, and to health management. Despite or even due to their small sizes, mitogenomes continue to surprise us. Studies of mitogenomes reveal the details of molecular organization and its evolution under constraints for miniaturization.

Evolution of Life

Evolution of Life
  • Author : Syozo Osawa,Tasuku Honjo
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • ISBN : 9784431683025
DOWNLOAD BOOKEvolution of Life

Nearly thirty million species of organisms are believed to now live on Earth. In addition to accumulating evidence from classical biology, paleontology and earth science, the recent progress of molecular biology has provided new insights into understanding how present-day organisms have evolved with such tremendous diversity. Molecular biological studies show us that all living forms, including E. coli and human beings, derive from a single ancestor that emerged some 4 billion years ago on Earth. This volume aims to discuss the

Molecular Biology of the Cell

Molecular Biology of the Cell
  • Author : Bruce Alberts
  • Publisher : Unknown
  • Release Date : 2004
  • ISBN : 0815332181
DOWNLOAD BOOKMolecular Biology of the Cell

The Chlamydomonas Sourcebook: Introduction to Chlamydomonas and Its Laboratory Use

The Chlamydomonas Sourcebook: Introduction to Chlamydomonas and Its Laboratory Use
  • Author : Elizabeth H. Harris
  • Publisher : Academic Press
  • Release Date : 2009-03-07
  • ISBN : 0080919553
DOWNLOAD BOOKThe Chlamydomonas Sourcebook: Introduction to Chlamydomonas and Its Laboratory Use

Dr. Harris has played a major role in the development of this organism as a model system. Her previous version of the Chlamydomonas Sourcebook which published in 1989, has been a classic in the field and is considered required reading for anyone working with this organism. This latest edition has been expanded to include three volumes providing molecular techniques, analysis of the recently sequenced genome, and reviews of the current status of the diverse fields in which Chlamydomonas is used as