Mesenchymal Stem Cell Therapy

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  • Publisher : Springer Science & Business Media
  • Release : 12 December 2012
  • ISBN : 9781627032001
  • Page : 456 pages
  • Rating : 4.5/5 from 103 voters

Mesenchymal Stem Cell Therapy Book PDF summary

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

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Mesenchymal Stem Cell Therapy

Mesenchymal Stem Cell Therapy
  • Author : Lucas G. Chase,Mohan C Vemuri
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-12
  • ISBN : 9781627032001
DOWNLOAD BOOKMesenchymal Stem Cell Therapy

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host

Orthopedic Stem Cell Surgery

Orthopedic Stem Cell Surgery
  • Author : Jeffrey N. Weiss
  • Publisher : Springer Nature
  • Release Date : 2021
  • ISBN : 9783030732998
DOWNLOAD BOOKOrthopedic Stem Cell Surgery

This book is a concise guide that provides an easy to follow template for other physicians to develop similar stem cell based treatments within their specialty. It identifies and summarizes the current world-wide orthopedic stem cell trials. Organized into three sections, Orthopedic Stem Cell Surgery presents clinical studies that examine the procedures for setting up and implementing stem cell surgery within the specialty of orthopedics. Chapters maintain an accessible narrative while also addressing complex studies related to orthopedic stem cell

Interface Oral Health Science 2016

Interface Oral Health Science 2016
  • Author : Keiichi Sasaki,Osamu Suzuki,Nobuhiro Takahashi
  • Publisher : Springer
  • Release Date : 2016-12-08
  • ISBN : 9789811015601
DOWNLOAD BOOKInterface Oral Health Science 2016

This book is open access under a CC BY 4.0 license. This volume broadens understanding of dentistry and promotes interdisciplinary research across a wide range of related fields, based on the symposium entitled "Innovative Research for Biosis–Abiosis Intelligent Interface 2016". It aims to create highly functional and autonomic intelligent interface by combining highly functional interface science with the technology of an evaluation and a control at the interface, with the various topics of biomaterials, innovation for oral science and application, regenerative

Bone and Cartilage Regeneration

Bone and Cartilage Regeneration
  • Author : Phuc Van Pham
  • Publisher : Springer
  • Release Date : 2017-01-24
  • ISBN : 9783319401447
DOWNLOAD BOOKBone and Cartilage Regeneration

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in bone and cartilage regeneration. Each chapter is contributed by a pre-eminent scientist in the field and covers such topics as skeletal regeneration by mesenchymal stem cells, clinical improvement of mesenchymal stem cell injection in injured cartilage and osteoarthritis, Good manufacturing practice (GMP), minimal critera of stem cells for clinical applications, future directions of the discussed therapies and much more. Bone & Cartilage Regeneration and the

Orthobiologics

Orthobiologics
  • Author : Giuseppe Filardo,Bert R. Mandelbaum,George F. Muschler,Scott A. Rodeo,Norimasa Nakamura
  • Publisher : Springer Nature
  • Release Date : 2021-12-02
  • ISBN : 9783030847449
DOWNLOAD BOOKOrthobiologics

This book presents the evidence related to the use of injectable biologics to provide faster and better healing for musculoskeletal lesions and conditions. The authors discuss approaches, such as blood derivatives and cell concentrates, applied to lesions of muscles, ligaments, tendons, bones, meniscus and cartilage, as well as osteoarthritis. Chapters are written by some of the most influential opinion leaders in the field, with up-to-date review of the current literature, where the authors explore both the potential and the limitations

Cardiac Regeneration

Cardiac Regeneration
  • Author : Masaki Ieda,Wolfram-Hubertus Zimmermann
  • Publisher : Springer
  • Release Date : 2017-10-27
  • ISBN : 9783319561066
DOWNLOAD BOOKCardiac Regeneration

This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when,

Regenerative Medicine for Spine and Joint Pain

Regenerative Medicine for Spine and Joint Pain
  • Author : Grant Cooper,Joseph Herrera,Jason Kirkbride,Zachary Perlman
  • Publisher : Springer
  • Release Date : 2021-05-15
  • ISBN : 3030427730
DOWNLOAD BOOKRegenerative Medicine for Spine and Joint Pain

Regenerative medicine (RM) is a rapidly expanding topic within orthopedic and spine surgery, sports medicine and rehabilitation medicine. In the last ten years, regenerative medicine has emerged from the fringes as a complement and challenge to evidence-based medicine. Both clinicians and patients alike are eager to be able to offer and receive treatments that don't just surgically replace or clean old joints or inject away inflammation or work as a stop-gap measure. Regenerative medicine encompasses everything from the use of

Cartilage Repair and Regeneration

Cartilage Repair and Regeneration
  • Author : Alessandro Rozim Zorzi,João Batista de Miranda
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-02-14
  • ISBN : 9789535137887
DOWNLOAD BOOKCartilage Repair and Regeneration

This work is the result of a partnership that began in 2011, when I received for the first time the invitation to be the scientific editor of a book on bone grafting, by the still little publisher known as InTech. Now six years later, InTech has grown and thrived. My respect and warm approval for the quality of the publisher's work only increased. The hyaline cartilage is a tissue that challenges tissue engineering and regenerative medicine because of its avascular nature.

Stem Cell Therapy as an Alternative for Osteoarthritis of the Knee

Stem Cell Therapy as an Alternative for Osteoarthritis of the Knee
  • Author : Jessica Wornham
  • Publisher : Unknown
  • Release Date : 2020
  • ISBN : OCLC:1287090976
DOWNLOAD BOOKStem Cell Therapy as an Alternative for Osteoarthritis of the Knee

Update on Mesenchymal and Induced Pluripotent Stem Cells

Update on Mesenchymal and Induced Pluripotent Stem Cells
  • Author : Khalid Ahmed Al-Anazi
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-04-22
  • ISBN : 9781789238075
DOWNLOAD BOOKUpdate on Mesenchymal and Induced Pluripotent Stem Cells

This book represents an updated overview on selected topics related to mesenchymal stem cells as well as induced pluripotent stem cells. The book is divided into three main sections that cover several topics including: sources of both stem cell types, their preparation and general properties, as well as their therapeutic indications and clinical utilization with particular attention given to their use in infectious diseases, osteoarthritis, as well as immunological disorders.

Early Osteoarthritis

Early Osteoarthritis
  • Author : Christian Lattermann,Henning Madry,Norimasa Nakamura,Elizaveta Kon
  • Publisher : Springer Nature
  • Release Date : 2021-10-09
  • ISBN : 9783030794859
DOWNLOAD BOOKEarly Osteoarthritis

Early osteoarthritis is novel topic for orthopedic surgeons and its process begins immediately after joint injury. The mechanical restoration of the joint surface or ligamentous stability is not sufficient to restore the homeostatic environment in the joint, and this leads to osteoarthritis, despite mechanical stability and alignment. This book sheds light on the various mechanisms and systems involved in the gradual decline of the injured joint toward manifest osteoarthritis. Published in collaboration with ISAKOS, this volume appeals to all stakeholders

Mesenchymal Stem Cells in Human Health and Diseases

Mesenchymal Stem Cells in Human Health and Diseases
  • Author : Ahmed El-Hashash
  • Publisher : Academic Press
  • Release Date : 2020-01-06
  • ISBN : 9780128197134
DOWNLOAD BOOKMesenchymal Stem Cells in Human Health and Diseases

Mesenchymal Stem Cells in Human Health and Diseases provides a contemporary overview of the fast-moving field of MSC biology, regenerative medicine and therapeutics. MSCs offer the potential to dramatically reduce human suffering from disease. Numerous MSC-based studies are ongoing each year, each offering hope for novel treatments in human disease. This book provides information on MSC application in well-studied human diseases and tissue repair/regeneration and recent advances in their research and treatment. These discoveries are placed within the structural

Peripheral Nerve Stimulation

Peripheral Nerve Stimulation
  • Author : K.V. Slavin
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2011-03-24
  • ISBN : 9783805594899
DOWNLOAD BOOKPeripheral Nerve Stimulation

In a rapidly growing field of neuromodulation against pain, this excellent publication presents a unique compilation of the latest theoretical and practical information for electrical stimulation of the peripheral nerves. Chapters cover the use of peripheral nerve stimulation in particular indications such as migraine, cluster headache, pain in Chiari malformation and fibromyalgia, as well as in specific body parts such as head and neck, trunk, and extremities. Furthermore, chapters on history, technical aspects, mechanism of action, terminology, complications and other

Stem Cells for Osteoarthritis Volume 2

Stem Cells for Osteoarthritis Volume 2
  • Author : Nathan Wei
  • Publisher : Unknown
  • Release Date : 2014-10-28
  • ISBN : 1503017486
DOWNLOAD BOOKStem Cells for Osteoarthritis Volume 2

Osteoarthritis is the most common form of arthritis... but like Rodney Dangerfield, it doesn't get much respect. The reason is that it is so hard to treat.The types of management techniques used haven't changed in almost forty years. Very few pharmaceutical and biotech companies are willing to tackle osteoarthritis because it is such a difficult task. The number of clinical trials involving new therapies for osteoarthritis is riddled with the bodies of the fallen.For those of us in

Stem Cell Revolution

Stem Cell Revolution
  • Author : Joseph Christiano
  • Publisher : Charisma Media
  • Release Date : 2018-01-16
  • ISBN : 9781629995076
DOWNLOAD BOOKStem Cell Revolution

The Answer to Your Health Problems IS NOT WHAT YOU EXPECT What is adult stem cell therapy? Are there different adult stem cell treatment options? What type of conditions does adult stem cell therapy treat? What is the success rate? How much does it cost? Are there any risks or side effects? What's so great about adult stem cell therapy? Joseph "Dr. Joe" Christiano clears away the confusion surrounding this groundbreaking new treatment. Discover how stem cell activators target adult