Protein Homeostasis Diseases

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  • Publisher : Academic Press
  • Release : 13 February 2020
  • ISBN : 9780128191330
  • Page : 450 pages
  • Rating : 4.5/5 from 103 voters

Protein Homeostasis Diseases Book PDF summary

Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders. Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance

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Protein Homeostasis Diseases

Protein Homeostasis Diseases
  • Author : Angel L. Pey
  • Publisher : Academic Press
  • Release Date : 2020-02-13
  • ISBN : 9780128191330
DOWNLOAD BOOKProtein Homeostasis Diseases

Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters

Protein Homeostasis

Protein Homeostasis
  • Author : Richard I. Morimoto,Dennis J. Selkoe,Jeffery W. Kelly
  • Publisher : Unknown
  • Release Date : 2012
  • ISBN : 1936113066
DOWNLOAD BOOKProtein Homeostasis

Proper expression, folding, transport, and clearance of proteins is critical for cell function. Chaperones and enzymes that posttranslationally assist newly synthesized proteins help ensure that they fold correctly or are degraded. Translocation machineries, proteasomes, and autophagic activities help to localize and degrade proteins as necessary. Stress and aging can cause such mechanisms to become dysfunctional or overloaded, resulting in the accumulation and aggregation of misfolded proteins a feature of numerous neurodegenerative conditions. Written and edited by experts in the field,

Protein Homeostasis, Second Edition

Protein Homeostasis, Second Edition
  • Author : Richard I. Morimoto,Jeffery W. Kelly,F. Ulrich Hartl
  • Publisher : Perspectives Cshl
  • Release Date : 2019
  • ISBN : 1621822966
DOWNLOAD BOOKProtein Homeostasis, Second Edition

The entire life cycle of a protein-from synthesis and folding to transport and degradation-is carefully controlled by the proteostasis network. This network, consisting of many interconnected pathways and processes, manages protein homeostasis by dynamically responding to the needs of the cell. Stress and aging can challenge the proteostasis network, resulting in the aggregation of misfolded proteins-a feature of numerous neurodegenerative conditions. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a

Proteostasis and Proteolysis

Proteostasis and Proteolysis
  • Author : Niki Chondrogianni,Elah Pick,Anna Gioran
  • Publisher : CRC Press
  • Release Date : 2022-12-23
  • ISBN : 9781000474589
DOWNLOAD BOOKProteostasis and Proteolysis

Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system: the ubiquitin-proteasome system and autophagy.

Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases

Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases
  • Author : Diana Fernandes L├ízaro,Tiago F. Outeiro,Arianna Bellucci,Patrik Brundin
  • Publisher : Frontiers Media SA
  • Release Date : 2020-02-20
  • ISBN : 9782889635078
DOWNLOAD BOOKProtein Misfolding and Spreading Pathology in Neurodegenerative Diseases

Nature's Robots

Nature's Robots
  • Author : Charles Tanford,Jacqueline Reynolds
  • Publisher : OUP Oxford
  • Release Date : 2003-11-27
  • ISBN : 9780191578519
DOWNLOAD BOOKNature's Robots

Proteins are amazingly versatile molecules. They make the chemical reactions happen that form the basis for life, they transmit signals in the body, they identify and kill foreign invaders, they form the engines that make us move, and they record visual images. All of this is now common knowledge, but it was not so a hundred years ago. Nature's Robots is an authoritative history of protein science, from the origins of protein research in the nineteenth century, when the chemical

Proteolytic Signaling in Health and Disease

Proteolytic Signaling in Health and Disease
  • Author : Andre Zelanis
  • Publisher : Academic Press
  • Release Date : 2021-10-13
  • ISBN : 9780323856973
DOWNLOAD BOOKProteolytic Signaling in Health and Disease

In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound

Protein Metabolism and Homeostasis in Aging

Protein Metabolism and Homeostasis in Aging
  • Author : Nektarios Tavernarakis
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-01-11
  • ISBN : 9781441970022
DOWNLOAD BOOKProtein Metabolism and Homeostasis in Aging

Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism and chromosomal maintenance, together with protein metabolism are critical in the aging process. The focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein