Patient Derived Tumor Xenograft Models

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  • Publisher : Academic Press
  • Release : 13 October 2016
  • ISBN : 9780128040614
  • Page : 486 pages
  • Rating : 4.5/5 from 103 voters

Patient Derived Tumor Xenograft Models Book PDF summary

Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains. In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included, as is a discussion of the facilities and infrastructure required to operate a PDX laboratory. Offers guidance on data interpretation and regulatory aspects Provides useful techniques and strategies for working with PDX models Includes practical tools and potential pitfalls for best practices Compiles all knowledge of PDX models research in one resource Presents the results of first ever global survey on standards of PDX development and usage in academia and industry

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Patient Derived Tumor Xenograft Models

Patient Derived Tumor Xenograft Models
  • Author : Rajesh Uthamanthil,Peggy Tinkey,Elisa de Stanchina
  • Publisher : Academic Press
  • Release Date : 2016-10-13
  • ISBN : 9780128040614
DOWNLOAD BOOKPatient Derived Tumor Xenograft Models

Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains. In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included, as is

Patient-Derived Mouse Models of Cancer

Patient-Derived Mouse Models of Cancer
  • Author : Robert M. Hoffman
  • Publisher : Springer
  • Release Date : 2017-08-01
  • ISBN : 9783319574240
DOWNLOAD BOOKPatient-Derived Mouse Models of Cancer

This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also

Tumor Models in Cancer Research

Tumor Models in Cancer Research
  • Author : Beverly A. Teicher
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-12-01
  • ISBN : 9781607619680
DOWNLOAD BOOKTumor Models in Cancer Research

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some

Patient-derived Xenograft Models of Human Cancer

Patient-derived Xenograft Models of Human Cancer
  • Author : Yuzhuo Wang,Dong Lin,Peter W. Gout
  • Publisher : Unknown
  • Release Date : 2017
  • ISBN : 3319558269
DOWNLOAD BOOKPatient-derived Xenograft Models of Human Cancer

This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing

Handbook of Cancer Models with Applications

Handbook of Cancer Models with Applications
  • Author : W. Y. Tan
  • Publisher : World Scientific
  • Release Date : 2008
  • ISBN : 9789812779489
DOWNLOAD BOOKHandbook of Cancer Models with Applications

Composed of contributions from an international team of leading researchers, this book pulls together the most recent research results in the field of cancer modeling to provide readers with the most advanced mathematical models of cancer and their applications.Topics included in the book cover oncogenetic trees, stochastic multistage models of carcinogenesis, effects of ionizing radiation on cell cycle and genomic instability, induction of DNA damage by ionizing radiation and its repair, epigenetic cancer models, bystander effects of radiation, multiple

Translational Research in Breast Cancer

Translational Research in Breast Cancer
  • Author : Dong-Young Noh,Wonshik Han,Masakazu Toi
  • Publisher : Springer Nature
  • Release Date : 2021-05-13
  • ISBN : 9789813296206
DOWNLOAD BOOKTranslational Research in Breast Cancer

This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in

Patient-Derived Xenograft Models of Human Cancer

Patient-Derived Xenograft Models of Human Cancer
  • Author : Yuzhuo Wang,Dong Lin,Peter W. Gout
  • Publisher : Springer
  • Release Date : 2017-06-27
  • ISBN : 9783319558257
DOWNLOAD BOOKPatient-Derived Xenograft Models of Human Cancer

This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing

Tumor Organoids

Tumor Organoids
  • Author : Shay Soker,Aleksander Skardal
  • Publisher : Humana Press
  • Release Date : 2017-10-20
  • ISBN : 9783319605111
DOWNLOAD BOOKTumor Organoids

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering

Cancer Models

Cancer Models
  • Author : Michael Breitenbach,Jens Hoffmann
  • Publisher : Frontiers Media SA
  • Release Date : 2019-02-05
  • ISBN : 9782889457014
DOWNLOAD BOOKCancer Models

Cancer research, like research on other diseases, highly depends on representative and reliable model systems. In the Research Topic “Cancer Models”, we collected original papers and review articles addressing the topic of tumor modeling from molecular biology, biochemistry, microorganisms, cells and organoids, fishes, animals and xenografts, up to computational cancer models and patient data analysis. This representative eBook describes that there is not a single molecular defined tumor but rather a heterogenic and highly variable complex of different individual diseases.

Anticancer Drug Development Guide

Anticancer Drug Development Guide
  • Author : Beverly A. Teicher,Paul A. Andrews
  • Publisher : Springer Science & Business Media
  • Release Date : 2004-02-01
  • ISBN : 9781592597390
DOWNLOAD BOOKAnticancer Drug Development Guide

This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules.

Human Tumor Cells in Vitro

Human Tumor Cells in Vitro
  • Author : Jorgen Fogh
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-06-29
  • ISBN : 9781475716474
DOWNLOAD BOOKHuman Tumor Cells in Vitro

The study of cultured human tumor cells is a most obvious approach in experimental human cancer research. For many techniques in virology, immunology, biochemistry, and biophysics, for example, large amounts of cells may be required and such quantities are usually provided only when the cultures develop into established cell lines; when this happens, thorough characterization also becomes possible. The development of cell lines, therefore, is of prime importance. Recent major advances in research with animal cell systems see m to

Esophageal Squamous Cell Carcinoma

Esophageal Squamous Cell Carcinoma
  • Author : Alfred K. Lam
  • Publisher : Humana
  • Release Date : 2021-02-28
  • ISBN : 1071603795
DOWNLOAD BOOKEsophageal Squamous Cell Carcinoma

This volume provides current management and research protocols on oesophageal squamous cell carcinoma. Chapters guide readers through methods on clinical and pathological diagnostics, translational research for oesophageal squamous cell carcinoma, in vitro assays, liquid biopsy for cancer DNA and circulating tumour cells, genomic analysis, mi-RNAs, and proteins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on

Contemporary Multivariate Analysis and Design of Experiments

Contemporary Multivariate Analysis and Design of Experiments
  • Author : Kaitai Fang
  • Publisher : World Scientific
  • Release Date : 2005
  • ISBN : 9789812567765
DOWNLOAD BOOKContemporary Multivariate Analysis and Design of Experiments

Index. Subject index -- Author index

Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy

Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-11-21
  • ISBN : 9780128127384
DOWNLOAD BOOKProtein Kinase Inhibitors as Sensitizing Agents for Chemotherapy

Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy Series, focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have been used as sensitizing agents, such as EGFR, BCR-ABL, ALK and BRAF. In each chapter, readers will find comprehensive knowledge on the inhibitor and its action, including its biochemical, genetic,

Cancer Cell Culture

Cancer Cell Culture
  • Author : Simon P. Langdon
  • Publisher : Springer Science & Business Media
  • Release Date : 2004
  • ISBN : 9781592594061
DOWNLOAD BOOKCancer Cell Culture

This volume describes easy to follow methods to guide both the novice and more experienced researcher seeking to use new techniques for the culture of cancer cells. The first section of the book introduces the rationale behind the selection of specific materials to help the reader choose culture conditions appropriate to their studies and the general techniques operating in many culture facilities. The second section covers the specific requirements of the individual cancer cell types for optimal growth and maintenance.