Morphological Mouse Phenotyping

• Author : Jesus Ruberte,Ana Carretero,Marc Navarro
• Publisher : Elsevier
• Release Date : 2017
• ISBN : 9780128128770

• Author : Jesus Ruberte,Ana Carretero,Marc Navarro
• Publisher : Academic Press
• Release Date : 2016-12-15
• ISBN : 0128128054

Disease animal models are fundamental in research to improve human health. The success of using genetically engineered mice to evaluate molecular disease hypothesis has encouraged the development of massive global projects making the mouse the most used animal disease model. Laboratory mouse populations are straining the housing capacity of pharmaceutical and biotechnology companies, as well as public research institutions. However, the scientific community lacks sufficient expertise in morphological phenotyping to effectively characterize and validate these animal models. The mouse displays

• Author : Michael David Wong
• Publisher : Unknown
• Release Date : 2015
• ISBN : OCLC:1033014975

• Author : John P. Sundberg,Peter Vogel,Jerrold M. Ward
• Publisher : John Wiley & Sons
• Release Date : 2022-01-26
• ISBN : 9781119624578

An updated and comprehensive reference to pathology in every organ system in genetically modified mice The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and

• Author : Piper M. Treuting,Suzanne M. Dintzis
• Publisher : Academic Press
• Release Date : 2012-01
• ISBN : 9780123813619

Comparative Anatomy and Histology: A Mouse and Human Atlas is aimed at the new mouse investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse anatomy and histology using direct comparison to the human. The side by side comparison of mouse and human tissues highlight the unique biology of the mouse, which has great impact on the validation of mouse models of human

• Author : Naoyuki Tanimoto
• Publisher : Humana Press
• Release Date : 2018-03-22
• ISBN : 1493977199

The aim of this volume is to provide a wide range of techniques and aspects of mouse retinal phenotyping and characterization. Chapters guide readers through morphological and functional properties of the mouse retina and techniques for the analysis of outer to mid-retina and mid- to inner retina. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on

• Author : Andreas Deutsch,Rafael Bravo de la Parra,Rob J. de Boer,Odo Diekmann,Peter Jagers,Eva Kisdi,Mirjam Kretzschmar,Petr Lansky,Hans Metz
• Publisher : Springer Science & Business Media
• Release Date : 2007-10-12
• ISBN : 9780817645564

Volume II of this two-volume, interdisciplinary work is a unified presentation of a broad range of state-of-the-art topics in the rapidly growing field of mathematical modeling in the biological sciences. Highlighted throughout are mathematical and computational apporaches to examine central problems in the life sciences, ranging from the organization principles of individual cells to the dynamics of large populations. The chapters are thematically organized into the following main areas: epidemiology, evolution and ecology, immunology, neural systems and the brain, and

• Author : Hannsjörg Schröder,Natasha Moser,Stefan Huggenberger
• Publisher : Springer Nature
• Release Date : 2020-02-28
• ISBN : 9783030198985

This textbook describes the basic neuroanatomy of the laboratory mouse. The reader will be guided through the anatomy of the mouse nervous system with the help of abundant microphotographs and schemata. Learning objectives and summaries of key facts at the beginning of each chapter provide the reader with an overview on the most important information. As transgenic mice are one of the most widely used paradigms when it comes to modeling human diseases, a basic understanding of the neuroanatomy of

• Author : Cord Brakebusch,Taina Pihlajaniemi
• Publisher : Springer Science & Business Media
• Release Date : 2011-03-29
• ISBN : 9789400707504

Cell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the previous decades have produced a wealth of mechanistic information in all areas of biomedical research. Such in vitro research, however, lacks the complexity of in vivo investigations, where many different cell types interact with each other in a normal, three-dimensional environment, with normal levels of cytokines and growth factors. Furthermore, complex human diseases, such as cancer, diabetes or

• Author : Kenneth Douglas
• Publisher : Oxford University Press
• Release Date : 2021
• ISBN : 9780190943547

"Bioprinting: To Make Ourselves Anew describes how bioprinting emerged from 3D printing and details the accomplishments and challenges in bioprinting tissues of cartilage, skin, bone, muscle, neuromuscular junctions, liver, heart, lung, and kidney. It explains how scientists are attempting to provide these bioprinted tissues with a blood supply and the ability to carry nerve signals so that the tissues might be used for transplantation into persons with diseased or damaged organs. The book presents all the common terms in the

• Author : P. Nagarajan,Ramachandra Gudde,Ramesh Srinivasan
• Publisher : Springer Nature
• Release Date : 2021-07-23
• ISBN : 9789811609879

This book comprehensively reviews the anatomy, physiology, genetics and pathology of laboratory animals as well as the principles and practices of using laboratory animals for biomedical research.It covers the design of buildings used for laboratory animals, quality control of laboratory animals, and toxicology, and discusses various animal models used for human diseases. It also highlights aspects, such as handling and restraint and administration of drugs, as well as breeding and feeding of laboratory animals, and provides guidelines for developing

• Author : Brad Bolon
• Publisher : CRC Press
• Release Date : 2015-04-24
• ISBN : 9781420070095

Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology experimentation in mice but, more importantly, a "how to interpret" resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining

• Author : Ting-Chung Poon,Yaping Zhang,Liangcai Cao
• Publisher : MDPI
• Release Date : 2021-02-19
• ISBN : 9783039435951

Modern holographic techniques have been successfully applied in many important areas, such as 3-D inspection, 3-D microscopy, metrology, and profilometry, augmented reality, and industrial informatics. This Special Issue covers selected pieces of cutting-edge research works, ranging from low-level acquisition, to high-level analysis, processing, and manipulation of holographic information. The Special Issue also serves as a comprehensive review of existing state-of-the-art techniques in 3-D imaging and 3-D display, as well as broad insights into the future development of these disciplines. The

• Author : Richard Baldock,Jonathan Bard,Duncan Davidson,Gillian Morriss-Kay
• Publisher : Academic Press
• Release Date : 2015-09-23
• ISBN : 9780128009130

Kaufman's Atlas of Mouse Development: With Coronal Sections continues the stellar reputation of the original Atlas by providing updated, in-depth anatomical content and morphological views of organ systems.The publication offers written descriptions of the developmental origins of the organ systems alongside high-resolution images for needed visualization of developmental processes. Matt Kaufman himself has annotated the coronal images in the same clear, meticulous style of the original Atlas. Kaufman's Atlas of Mouse Development: With Coronal Sections follows the original Atlas

• Author : Jim J. Hagan
• Publisher : Springer Science & Business Media
• Release Date : 2011-04-02
• ISBN : 9783642197031

The development of more effective treatments for neuropsychiatric disorders requires scientific progress on a broad front. Animal models have a vital role to play in advancing the field. When deployed in conjunction with detailed study of these diseases in man they bring the power to make controlled experimental interventions which allow the functional consequences of genetic variations and polymorphisms to be understood in terms of their cellular, systems and behavioural effects. Further, they provide a means by which complex cognitive