Basic Principles of Drug Discovery and Development

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  • Publisher : Academic Press
  • Release : 30 March 2021
  • ISBN : 9780128172155
  • Page : 712 pages
  • Rating : 4.5/5 from 103 voters

Basic Principles of Drug Discovery and Development Book PDF summary

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist’s early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry

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Basic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development
  • Author : Benjamin E. Blass
  • Publisher : Academic Press
  • Release Date : 2021-03-30
  • ISBN : 9780128172155
DOWNLOAD BOOKBasic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and

Managing the Drug Discovery Process

Managing the Drug Discovery Process
  • Author : Walter Moos,Susan Miller,Stephen Munk,Barbara Munk
  • Publisher : Woodhead Publishing
  • Release Date : 2016-11-08
  • ISBN : 9780081006320
DOWNLOAD BOOKManaging the Drug Discovery Process

Managing the Drug Discovery Process: How to Make It More Efficient and Cost-Effective thoroughly examines the current state of pharmaceutical research and development by providing chemistry-based perspectives on biomedical research, drug hunting and innovation. The book also considers the interplay of stakeholders, consumers, and the drug firm with attendant factors, including those that are technical, legal, economic, demographic, political, social, ecological, and infrastructural. Since drug research can be a high-risk, high-payoff industry, it is important to researchers to effectively and

Drug Discovery and Development, Third Edition

Drug Discovery and Development, Third Edition
  • Author : James J. O'Donnell,John Somberg,Vincent Idemyor,James T. O'Donnell
  • Publisher : CRC Press
  • Release Date : 2019-12-13
  • ISBN : 9781351625135
DOWNLOAD BOOKDrug Discovery and Development, Third Edition

Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the

The Process of New Drug Discovery and Development

The Process of New Drug Discovery and Development
  • Author : G. Smith Charles
  • Publisher : CRC Press
  • Release Date : 1992-08-24
  • ISBN : 0849342112
DOWNLOAD BOOKThe Process of New Drug Discovery and Development

The Process of New Drug Discovery and Development presents a practical methodology for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It includes detailed discussions regarding the research process and presents critiques of the governmental regulatory aspects of pharmaceutical research. The author also addresses the controversy surrounding the use of animals in biomedical research and provides current information regarding the field of biotechnology, international drug research, and registration activities. The Process

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
  • Publisher : National Academies Press
  • Release Date : 2014-02-06
  • ISBN : 9780309292498
DOWNLOAD BOOKImproving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective

Drug Discovery and Development - E-Book

Drug Discovery and Development - E-Book
  • Author : Raymond G Hill
  • Publisher : Elsevier Health Sciences
  • Release Date : 2012-07-20
  • ISBN : 9780702053160
DOWNLOAD BOOKDrug Discovery and Development - E-Book

The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries’ trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories

Industrialization of Drug Discovery

Industrialization of Drug Discovery
  • Author : Jeffrey S. Handen, Ph.D.
  • Publisher : CRC Press
  • Release Date : 2005-05-26
  • ISBN : 9781420028072
DOWNLOAD BOOKIndustrialization of Drug Discovery

The drug discovery and development process is getting longer, more expensive, and no better. The industry suffers from the same clinical attrition and safety-related market withdrawal rates today as it did 20 years ago. Industrialization of Drug Discovery: From Target Selection Through Lead Optimization scrutinizes these problems in detail, contrasting the promise of technology and industrialization with the challenges of using the tools available to their best advantage. The book explores early successes, examines the current state of the art, and

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : C. Robin Ganellin,Roy Jefferis,Stanley M. Roberts
  • Publisher : Academic Press
  • Release Date : 2013-05-07
  • ISBN : 9780123977700
DOWNLOAD BOOKIntroduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the

The Role of NIH in Drug Development Innovation and Its Impact on Patient Access

The Role of NIH in Drug Development Innovation and Its Impact on Patient Access
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Board on Health Care Services
  • Publisher : National Academies Press
  • Release Date : 2020-02-27
  • ISBN : 9780309498487
DOWNLOAD BOOKThe Role of NIH in Drug Development Innovation and Its Impact on Patient Access

To explore the role of the National Institutes of Health (NIH) in innovative drug development and its impact on patient access, the Board on Health Care Services and the Board on Health Sciences Policy of the National Academies jointly hosted a public workshop on July 24â€"25, 2019, in Washington, DC. Workshop speakers and participants discussed the ways in which federal investments in biomedical research are translated into innovative therapies and considered approaches to ensure that the public has affordable access to the

Managing the Drug Development Process

Managing the Drug Development Process
  • Author : Frank Basa,Thomas John Allen
  • Publisher : Unknown
  • Release Date : 1994
  • ISBN : OCLC:35570644
DOWNLOAD BOOKManaging the Drug Development Process

Managing the Drug Discovery Process

Managing the Drug Discovery Process
  • Author : Walter Moos,Susan Miller,Stephen Munk,Barbara Munk,David C. Spellmeyer,Charles Hart
  • Publisher : Elsevier
  • Release Date : 2023-01-01
  • ISBN : 9780128243053
DOWNLOAD BOOKManaging the Drug Discovery Process

Managing the Drug Discovery Process, Second Edition thoroughly examines the current state of pharmaceutical research and development by providing chemistry-based perspectives on biomedical research, drug hunting and innovation. The book also considers the interplay of stakeholders, consumers and the drug firm with attendant factors, including those that are technical, legal, economic, demographic, political, social, ecological and infrastructural. This new edition takes a closer look at increasing pre-approval costs for new drugs and examines not only why these increases occur, but

The Future of Drug Discovery

The Future of Drug Discovery
  • Author : Tamas Bartfai,Graham V. Lees
  • Publisher : Academic Press
  • Release Date : 2013-05-18
  • ISBN : 9780124095199
DOWNLOAD BOOKThe Future of Drug Discovery

The Future of Drug Discovery: Who decides which diseases to treat? provides a timely and detailed look at the efforts of the pharmaceutical industry and how they relate, or should relate, to societal needs. The authors posit that as a result of increasing risk aversion and accelerated savings in research and development, the industry is not developing drugs for increasingly prevalent diseases, such as Alzheimer’s disease, untreatable pain, antibiotics and more. This book carefully exposes the gap between the

Drug Discovery and Development

Drug Discovery and Development
  • Author : Omboon Vallisuta,Suleiman Olimat
  • Publisher : BoD – Books on Demand
  • Release Date : 2015-06-03
  • ISBN : 9789535121282
DOWNLOAD BOOKDrug Discovery and Development

It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against

Re-inventing Drug Development

Re-inventing Drug Development
  • Author : Jeffrey S. Handen
  • Publisher : CRC Press
  • Release Date : 2014-10-28
  • ISBN : 9781466579989
DOWNLOAD BOOKRe-inventing Drug Development

The biopharmaceutical industry has entered an era of unprecedented change and challenge, characterized by increasing pricing pressures, rising rates of attrition in the product development lifecycle, and decreasing scientific innovation. The most successful products are losing patent protection, and pipelines have been unable to fill the gap. This book explores the evolving definition of innovation in therapeutic product development and begins to examine its effects on the life sciences R&D industry. Historically, scientific innovation alone was sufficient to maintain

Theory of Drug Development

Theory of Drug Development
  • Author : Eric B. Holmgren
  • Publisher : CRC Press
  • Release Date : 2013-10-24
  • ISBN : 9781466507463
DOWNLOAD BOOKTheory of Drug Development

Theory of Drug Development presents a formal quantitative framework for understanding drug development that goes beyond simply describing the properties of the statistics in individual studies. It examines the drug development process from the perspectives of drug companies and regulatory agencies. By quantifying various ideas underlying drug development, the book shows how to systematically address problems, such as: Sizing a phase 2 trial and choosing the range of p-values that will trigger a follow-up phase 3 trial Deciding whether a drug should