Lean Biomanufacturing

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  • Publisher : Elsevier
  • Release : 31 October 2013
  • ISBN : 9781908818409
  • Page : 384 pages
  • Rating : 4.5/5 from 103 voters

Lean Biomanufacturing Book PDF summary

With decreasing profit margins, increasing cost pressures, growing regulatory compliance concerns, mounting pressure from generic drugs and increasing anxiety about the future of healthcare reimbursement, pharmaceutical manufacturers are now forced to re-examine and re-assess the way they have been doing things. In order to sustain profitability, these companies are looking to reduce waste (of all kinds), improve efficiency and increase productivity. Many of them are taking a closer look at lean manufacturing as a way to achieve these goals. Lean biomanufacturing re-visits lean principles and then applies them sympathetically - in a highly practical approach - to the specific needs of pharmaceutical processes, which present significantly different challenges to more mainstream manufacturing processes. A major goal of the book is to highlight those problems and issues that appear more specific or unique to biopharmaceutical manufacturing situations and to provide some insights into what challenges are the important ones to solve and what techniques, tools and mechanisms to employ to be successful. Following an introduction to lean biomanufacturing, the book goes on to discuss lean technologies and methods applied in biomanufacturing. Later chapters cover the creation and implementation of the Transition Plan, issues facing the biopharmaceutical industry, creating a lean approach towards biopharmaceutical processes and the contribution of simulation models in developing these processes. The final chapter covers examples of new technology innovations which help facilitate lean biomanufacturing. A focus on the issues associated with the application of lean principles to biomanufacturing Practical examples of factors which can affect biopharmaceutical processes Coverage of key factors which require integration to run an efficient biopharmaceutical process

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Lean Biomanufacturing

Lean Biomanufacturing
  • Author : Nigel J Smart
  • Publisher : Elsevier
  • Release Date : 2013-10-31
  • ISBN : 9781908818409
DOWNLOAD BOOKLean Biomanufacturing

With decreasing profit margins, increasing cost pressures, growing regulatory compliance concerns, mounting pressure from generic drugs and increasing anxiety about the future of healthcare reimbursement, pharmaceutical manufacturers are now forced to re-examine and re-assess the way they have been doing things. In order to sustain profitability, these companies are looking to reduce waste (of all kinds), improve efficiency and increase productivity. Many of them are taking a closer look at lean manufacturing as a way to achieve these goals. Lean

Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing

Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing
  • Author : Ganapathy Subramanian
  • Publisher : John Wiley & Sons
  • Release Date : 2021-12-15
  • ISBN : 9783527827336
DOWNLOAD BOOKProcess Control, Intensification, and Digitalisation in Continuous Biomanufacturing

Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing Explore new trends in continuous biomanufacturing with contributions from leading practitioners in the field With the increasingly widespread acceptance and investment in the ??technology, the last decade has demonstrated the utility of continuous ??processing in the pharmaceutical industry. In Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing, distinguished biotechnologist Dr. Ganapathy Subramanian delivers a comprehensive exploration of the potential of the continuous processing of biological products and discussions of future directions in

From Plant Genomics to Plant Biotechnology

From Plant Genomics to Plant Biotechnology
  • Author : Palmiro Poltronieri,Natalija Burbulis,Corrado Fogher
  • Publisher : Elsevier
  • Release Date : 2013-08-31
  • ISBN : 9781908818478
DOWNLOAD BOOKFrom Plant Genomics to Plant Biotechnology

With the appearance of methods for the sequencing of genomes and less expensive next generation sequencing methods, we face rapid advancements of the -omics technologies and plant biology studies: reverse and forward genetics, functional genomics, transcriptomics, proteomics, metabolomics, the movement at distance of effectors and structural biology. From plant genomics to plant biotechnology reviews the recent advancements in the post-genomic era, discussing how different varieties respond to abiotic and biotic stresses, understanding the epigenetic control and epigenetic memory, the roles

Matlab® in Bioscience and Biotechnology

Matlab® in Bioscience and Biotechnology
  • Author : Leonid Burstein
  • Publisher : Elsevier
  • Release Date : 2011-06-05
  • ISBN : 9781908818034
DOWNLOAD BOOKMatlab® in Bioscience and Biotechnology

MATLAB® in bioscience and biotechnology presents an introductory Matlab course oriented towards various collaborative areas of biotechnology and bioscience. It concentrates on Matlab fundamentals and gives examples of its application to a wide range of current bioengineering problems in computational biology, molecular biology, bio-kinetics, biomedicine, bioinformatics, and biotechnology. In the last decade Matlab has been presented to students as the first computer program they learn. Consequently, many non-programmer students, engineers and scientists have come to regard it as user-friendly and

Process Scale Purification of Antibodies

Process Scale Purification of Antibodies
  • Author : Uwe Gottschalk
  • Publisher : John Wiley & Sons
  • Release Date : 2017-04-03
  • ISBN : 9781119126911
DOWNLOAD BOOKProcess Scale Purification of Antibodies

Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification. • Updates existing topics and adds new ones that include purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing • Presents new and updated discussions of different purification technologies, focusing on how they can address the capacity crunch in antibody purification • Emphasizes

Operations Research

Operations Research
  • Author : Kuodi Jian
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-12-28
  • ISBN : 9789535128175
DOWNLOAD BOOKOperations Research

This book is dedicated to operations research of broad applications, such as improving informational bases of performance measurement with grey relational analysis, application of lean methodologies in a neurosurgery high dependency unit, iteration algorithms in Markov decision processes with state-action-dependent discount factors and unbounded costs, financial feasibility analysis of Natura Rab business case study, and mathematical modeling of isothermal drying and its potential application in the design of the industrial drying regimes of clay products.Operations research is an important

Process Architecture in Biomanufacturing Facility Design

Process Architecture in Biomanufacturing Facility Design
  • Author : Jeffery Odum,Michael C. Flickinger
  • Publisher : John Wiley & Sons
  • Release Date : 2018-01-26
  • ISBN : 9781118833650
DOWNLOAD BOOKProcess Architecture in Biomanufacturing Facility Design

Essential information for architects, designers, engineers, equipment suppliers, and other professionals who are working in or entering the biopharmaceutical manufacturing field Biomanufacturing facilities that are designed and built today are radically different than in the past. The vital information and knowledge needed to design and construct these increasingly sophisticated biopharmaceutical manufacturing facilities is difficult to find in published literature—and it’s rarely taught in architecture or design schools. This is the first book for architects and designers that fills

NMR Metabolomics in Cancer Research

NMR Metabolomics in Cancer Research
  • Author : Miroslava Čuperlović-Culf
  • Publisher : Elsevier
  • Release Date : 2012-12-17
  • ISBN : 9781908818263
DOWNLOAD BOOKNMR Metabolomics in Cancer Research

The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics