Late Stage Fluorination of Bioactive Molecules and Biologically Relevant Substrates

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  • Publisher : Elsevier
  • Release : 05 September 2018
  • ISBN : 9780128130391
  • Page : 390 pages
  • Rating : 4.5/5 from 103 voters

Late Stage Fluorination of Bioactive Molecules and Biologically Relevant Substrates Book PDF summary

Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work. Highlights the latest developments in the field in a concise volume Provides details of key fluorinating reagents across diverse families of organic compounds Explores the current applications and future potential of fluorine in drug development

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Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates

Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates
  • Author : Al Postigo
  • Publisher : Elsevier
  • Release Date : 2018-09-05
  • ISBN : 9780128130391
DOWNLOAD BOOKLate-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates

Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad

Nontraditional Activation Methods in Green and Sustainable Applications

Nontraditional Activation Methods in Green and Sustainable Applications
  • Author : Bela Torok,Christian Schaefer
  • Publisher : Elsevier
  • Release Date : 2021-02-28
  • ISBN : 9780128190159
DOWNLOAD BOOKNontraditional Activation Methods in Green and Sustainable Applications

Nontraditional Activation Methods in Green and Sustainable Applications: Microwaves; Ultrasounds; Photo-, Electro- and Mechan-ochemistry and High Hydrostatic Pressure provides a broad overview of non-traditional activation methods to help readers identify and use appropriate approaches in reducing the environmental impact of their work. Sections discuss the fundamental principles of each method and provide examples of their practical use, illustrating their usefulness. Given the importance of expanding laboratory based technologies to the industrial level, chapters that cover both existing and potential industrial

Organofluorine Chemistry

Organofluorine Chemistry
  • Author : Kalman J. Szabo,Nicklas Selander
  • Publisher : John Wiley & Sons
  • Release Date : 2021-01-05
  • ISBN : 9783527825141
DOWNLOAD BOOKOrganofluorine Chemistry

By presenting novel methods for the efficient preparation of fluorinated compounds and their application in pharmaceutical and agrochemical chemistry as well as medicine, this is a valuable source of information for all researchers in academia and industry!

Fluorine and Health

Fluorine and Health
  • Author : Alain Tressaud,Gunter Haufe
  • Publisher : Elsevier
  • Release Date : 2008-06-06
  • ISBN : 0080558119
DOWNLOAD BOOKFluorine and Health

Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive

C-H and C-X Bond Functionalization

C-H and C-X Bond Functionalization
  • Author : Xavi Ribas
  • Publisher : Royal Society of Chemistry
  • Release Date : 2013
  • ISBN : 9781849735704
DOWNLOAD BOOKC-H and C-X Bond Functionalization

Cross-coupling reactions involving C-H and C-X bond functionalisation are commonplace in natural product synthesis and natural products, therapeutic agents, biological probes, and advanced materials. Much attention has been given to understanding the mechanistic strategies used to achieve this, making this a hot topic in recent years. In this edited book, contributions from across the globe examine these strategies, with a particular focus on palladium and copper, as well as iron u an emerging element in this field. Reviewing the recent

Fluorination

Fluorination
  • Author : Jinbo Hu,Teruo Umemoto
  • Publisher : Springer
  • Release Date : 2020-08-12
  • ISBN : 9811038953
DOWNLOAD BOOKFluorination

This volume reviews the recent advances in formation of C-F bonds and X-F bonds (X = heteroatom) to produce useful fluorinated molecules for pharmaceuticals, materials and more. Reactions and methods associated with fluorination, including monofluorination, difluorination, trifluorination and other polyfluorination that have emerged within the past few years are systematically discussed. With contributions from front-line researchers in this field from both academia and industry, this book provides a valuable resource for scholars, graduate students as well as professionals.

Modern Synthesis Processes and Reactivity of Fluorinated Compounds

Modern Synthesis Processes and Reactivity of Fluorinated Compounds
  • Author : Henri Groult,Frederic Leroux,Alain Tressaud
  • Publisher : Elsevier
  • Release Date : 2016-11-04
  • ISBN : 9780128037904
DOWNLOAD BOOKModern Synthesis Processes and Reactivity of Fluorinated Compounds

Modern Synthesis Processes and Reactivity of Fluorinated Compounds focuses on the exceptional character of fluorine and fluorinated compounds. This comprehensive work explores examples taken from all classes of fluorine chemistry and illustrates the extreme reactivity of fluorinating media and the peculiar synthesis routes to fluorinated materials. The book provides advanced and updated information on the latest synthesis routes to fluorocompounds and the involved reaction mechanisms. Special attention is given to the unique reactivity of fluorine and fluorinated media, along with

Advances in Organic Synthesis

Advances in Organic Synthesis
  • Author : Atta-ur-Rahman,Kenneth K. Laali
  • Publisher : Bentham Science Publishers
  • Release Date : 2011-01-10
  • ISBN : 9781608051984
DOWNLOAD BOOKAdvances in Organic Synthesis

"The volume focuses on recent advances in organofluorine chemistry directed towards selective fluorine introduction into various target molecules, employing both traditional and contemporary, electrophilic and nucleophilic, fluorinating agents. It brings t"