Inhaled Medicines

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  • Publisher : Academic Press
  • Release : 05 February 2021
  • ISBN : 9780128149744
  • Page : 438 pages
  • Rating : 4.5/5 from 103 voters

Inhaled Medicines Book PDF summary

Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. ? Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact ? Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation ? Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field ? Provides systematic and thorough referencing to sources offering a more-in-depth analysis of technical issues

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Inhaled Medicines

Inhaled Medicines
  • Author : Stavros Kassinos,Per Bäckman,Joy Conway,Anthony J. J. Hickey
  • Publisher : Academic Press
  • Release Date : 2021-02-05
  • ISBN : 9780128149744
DOWNLOAD BOOKInhaled Medicines

Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches

Inhaled Pharmaceutical Product Development Perspectives

Inhaled Pharmaceutical Product Development Perspectives
  • Author : Anthony J. Hickey
  • Publisher : Elsevier
  • Release Date : 2017-11-23
  • ISBN : 9780128123362
DOWNLOAD BOOKInhaled Pharmaceutical Product Development Perspectives

Inhaled Pharmaceutical Product Development Perspectives: Challenges and Opportunities describes methods and procedures for consideration when developing inhaled pharmaceuticals, while commenting on product development strategies and their suitability to support regulatory submission. It bridges the gap between the aspirations of scientists invested in new technology development and the requirements that must be met for any new product. The book brings together emerging analytical and inhalation technologies, providing perspectives that illuminate formulation and device design, development, regulatory compliance, and practice. Focusing on

The Mechanics of Inhaled Pharmaceutical Aerosols

The Mechanics of Inhaled Pharmaceutical Aerosols
  • Author : Warren H. Finlay
  • Publisher : Academic Press
  • Release Date : 2019-06-01
  • ISBN : 9780081027868
DOWNLOAD BOOKThe Mechanics of Inhaled Pharmaceutical Aerosols

The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction, Second Edition provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols. This revised edition will allow researchers in the field to gain a thorough understanding of the field from first principles, allowing them to understand, design, develop and improve inhaled pharmaceutical aerosol devices and therapies. Chapters consider mechanics and deposition, specifically in the respiratory tract, while others discuss the mechanics associated with the three existing types

Inhaled Medicines

Inhaled Medicines
  • Author : Stavros Kassinos,Per Bäckman,Joy Conway,Anthony J. J. Hickey
  • Publisher : Academic Press
  • Release Date : 2021-01-20
  • ISBN : 9780128149751
DOWNLOAD BOOKInhaled Medicines

Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches

Pharmaceutical Inhalation Aerosol Technology, Second Edition

Pharmaceutical Inhalation Aerosol Technology, Second Edition
  • Author : Anthony J. Hickey
  • Publisher : CRC Press
  • Release Date : 2003-09-03
  • ISBN : 9780824756642
DOWNLOAD BOOKPharmaceutical Inhalation Aerosol Technology, Second Edition

This thoroughly revised and expanded reference provides authoritative discussions on the physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosol. It analyzes the latest science and developments in the generation, administration and characterization of these compounds, showcasing current clinical applications, the efficiency and limitations of major aerosol products and emerging aerosol therapies impacting the field.

Pharmaceutical Inhalation Aerosol Technology, Third Edition

Pharmaceutical Inhalation Aerosol Technology, Third Edition
  • Author : Anthony J. Hickey,Sandro R. da Rocha
  • Publisher : CRC Press
  • Release Date : 2019-03-26
  • ISBN : 9780429619564
DOWNLOAD BOOKPharmaceutical Inhalation Aerosol Technology, Third Edition

This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol

Living with Asthma: Manual for teaching parents the self-management of childhood asthma

Living with Asthma: Manual for teaching parents the self-management of childhood asthma
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1986
  • ISBN : SRLF:EE0000095273
DOWNLOAD BOOKLiving with Asthma: Manual for teaching parents the self-management of childhood asthma

Inhalation Aerosols

Inhalation Aerosols
  • Author : Anthony J. Hickey,Heidi M. Mansour
  • Publisher : CRC Press
  • Release Date : 2019-03-21
  • ISBN : 9781351660525
DOWNLOAD BOOKInhalation Aerosols

Inhalation aerosols continue to be the basis for successful lung therapy for several diseases, with therapeutic strategies and the range of technology significantly evolving in recent years. In response, this third edition takes a new approach to reflect the close integration of technology with its application. After briefly presenting the general considerations that apply to aerosol inhalation, the central section of the book uses the focus on disease and therapeutic agents to illustrate the application of specific technologies. The final

Public Health Consequences of E-Cigarettes

Public Health Consequences of E-Cigarettes
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on the Review of the Health Effects of Electronic Nicotine Delivery Systems
  • Publisher : National Academies Press
  • Release Date : 2018-05-18
  • ISBN : 9780309468374
DOWNLOAD BOOKPublic Health Consequences of E-Cigarettes

Millions of Americans use e-cigarettes. Despite their popularity, little is known about their health effects. Some suggest that e-cigarettes likely confer lower risk compared to combustible tobacco cigarettes, because they do not expose users to toxicants produced through combustion. Proponents of e-cigarette use also tout the potential benefits of e-cigarettes as devices that could help combustible tobacco cigarette smokers to quit and thereby reduce tobacco-related health risks. Others are concerned about the exposure to potentially toxic substances contained in e-cigarette

Marijuana As Medicine?

Marijuana As Medicine?
  • Author : Institute of Medicine,Janet Joy,Alison Mack
  • Publisher : National Academies Press
  • Release Date : 2000-12-30
  • ISBN : 9780309065313
DOWNLOAD BOOKMarijuana As Medicine?

Some people suffer from chronic, debilitating disorders for which no conventional treatment brings relief. Can marijuana ease their symptoms? Would it be breaking the law to turn to marijuana as a medication? There are few sources of objective, scientifically sound advice for people in this situation. Most books about marijuana and medicine attempt to promote the views of advocates or opponents. To fill the gap between these extremes, authors Alison Mack and Janet Joy have extracted critical findings from a

National Geographic

National Geographic
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2006-12
  • ISBN : STANFORD:36105122051738
DOWNLOAD BOOKNational Geographic

Difficult To Treat Asthma

Difficult To Treat Asthma
  • Author : Sandhya Khurana,Fernando Holguin
  • Publisher : Springer Nature
  • Release Date : 2019-08-29
  • ISBN : 9783030208127
DOWNLOAD BOOKDifficult To Treat Asthma

This book provides a practical, stepwise, evidence-based approach to effective management of patients with difficult to treat asthma. The impact of asthma on morbidity and healthcare utilization increases exponentially with severity. Severe refractory asthma accounts for less than 5% of all asthma. Its prevalence, however, is often overestimated as there are several other confounding factors that make asthma ‘difficult to treat’. Many novel (albeit expensive) therapies are now available and providers caring for patients with severe asthma are charged with selecting

Natural Ventilation for Infection Control in Health-care Settings

Natural Ventilation for Infection Control in Health-care Settings
  • Author : Y. Chartier,C. L Pessoa-Silva
  • Publisher : World Health Organization
  • Release Date : 2009
  • ISBN : 9789241547857
DOWNLOAD BOOKNatural Ventilation for Infection Control in Health-care Settings

This guideline defines ventilation and then natural ventilation. It explores the design requirements for natural ventilation in the context of infection control, describing the basic principles of design, construction, operation and maintenance for an effective natural ventilation system to control infection in health-care settings.

Oxford Desk Reference: Critical Care

Oxford Desk Reference: Critical Care
  • Author : Carl Waldmann,Neil Soni,Andrew Rhodes
  • Publisher : OUP Oxford
  • Release Date : 2008-11-27
  • ISBN : 9780191551994
DOWNLOAD BOOKOxford Desk Reference: Critical Care

Critical care medicine is an evolving speciality in which the amount of available information is growing daily and spread across a myriad of books, journals and websites. This essential guide brings together this information in an easy-to-use format. Up-to-date, relevant, and evidence-based information on the management of the critically ill is combined in one resource, ideal for the use of Intensive Care Units, High Dependency Units, acute medical or surgical wards, Accident and Emergency departments and operating theatres. The book

The Health Effects of Cannabis and Cannabinoids

The Health Effects of Cannabis and Cannabinoids
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda
  • Publisher : National Academies Press
  • Release Date : 2017-03-31
  • ISBN : 9780309453073
DOWNLOAD BOOKThe Health Effects of Cannabis and Cannabinoids

Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk. However, despite this changing landscape, evidence regarding the