Epigenetics of Chronic Pain

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  • Publisher : Academic Press
  • Release : 29 October 2018
  • ISBN : 9780128140710
  • Page : 248 pages
  • Rating : 4.5/5 from 103 voters

Epigenetics of Chronic Pain Book PDF summary

Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies. The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs. Compiles all known information on epigenetic regulation of chronic pain in one volume Covers the basic functionality of epigenetic mechanisms involved in pain management, applications of recent research in understanding different types of chronic pain, and pathways for developing therapeutics Leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss epigenetics in inflammatory, neuropathic, visceral, and other pain models in-depth Enables clinicians, researchers, and pharmacologists to better understand and treat chronic pain

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Epigenetics of Chronic Pain

Epigenetics of Chronic Pain
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-10-29
  • ISBN : 9780128140710
DOWNLOAD BOOKEpigenetics of Chronic Pain

Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined,

Chronic Pain and DNA Methylation in the Mouse Prefrontal Cortex

Chronic Pain and DNA Methylation in the Mouse Prefrontal Cortex
  • Author : Lucas Topham
  • Publisher : Unknown
  • Release Date : 2021
  • ISBN : OCLC:1257325454
DOWNLOAD BOOKChronic Pain and DNA Methylation in the Mouse Prefrontal Cortex

"Chronic pain is one of the leading causes of disability and reduced quality of life worldwide. As a result of chronic pain, the prefrontal cortex (PFC) undergoes significant structural and functional remodeling, resulting in the loss of grey matter, altered synapse formation, and changes in neurotransmitter and ion channel signalling. These changes are accompanied by widespread alterations in gene expression and can be reversed if pain is attenuated by therapeutic intervention. The combination of widespread changes in gene expression with

The Genetics of Pain

The Genetics of Pain
  • Author : Jeffrey Steven Mogil
  • Publisher : International Assn for the Study of Pain
  • Release Date : 2004
  • ISBN : UOM:39015059102452
DOWNLOAD BOOKThe Genetics of Pain

Genetics more than any other biological approach can explain why some people experience more pain than others and receive less benefit from existing analgesics. Sixteen scholarly articles from international contributors describe the application of genetic techniques to the problem of pain and consider the knowledge that has so far resulted. Three themed sections review the techniques that are allowing the study of pain mechanisms at the genetic level; describe the progress being made in lab animals and humans in identifying

Epigenetics of Aging

Epigenetics of Aging
  • Author : Trygve O. Tollefsbol
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-11-11
  • ISBN : 9781441906397
DOWNLOAD BOOKEpigenetics of Aging

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major

The Neurobiological Basis of Suicide

The Neurobiological Basis of Suicide
  • Author : Yogesh Dwivedi
  • Publisher : CRC Press
  • Release Date : 2012-06-25
  • ISBN : 9781439838815
DOWNLOAD BOOKThe Neurobiological Basis of Suicide

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they

Chronic Pain Epidemiology

Chronic Pain Epidemiology
  • Author : Fiona M. Blyth,Danielle van der Windt
  • Publisher : Oxford University Press
  • Release Date : 2010-09-30
  • ISBN : 9780199235766
DOWNLOAD BOOKChronic Pain Epidemiology

This book provides an invaluable framework and basis for thinking about chronic pain and the potential for its prevention in public health terms.

The Disease Delusion

The Disease Delusion
  • Author : Dr. Jeffrey S. Bland
  • Publisher : Harper Collins
  • Release Date : 2014-05-06
  • ISBN : 9780062290755
DOWNLOAD BOOKThe Disease Delusion

For decades, Dr. Jeffrey Bland has been on the cutting edge of Functional Medicine, which seeks to pinpoint and prevent the cause of illness, rather than treat its symptoms. Managing chronic diseases accounts for three quarters of our total healthcare costs, because we’re masking these illnesses with pills and temporary treatments, rather than addressing their underlying causes, he argues. Worse, only treating symptoms leads us down the path of further illness. In The Disease Delusion, Dr. Bland explains what

Translating Epigenetics to the Clinic

Translating Epigenetics to the Clinic
  • Author : Jeffrey Laurence
  • Publisher : Academic Press
  • Release Date : 2016-12-30
  • ISBN : 9780128006122
DOWNLOAD BOOKTranslating Epigenetics to the Clinic

Translating Epigenetics to the Clinic reviews current methodological tools and experimental approaches used by leading translational researchers seeking to use epigenetics as a clinical model. It organizes epigenetics into disease treatment areas with a major focus on oncology, and with much coverage of pervasive treatment categories such as diabetes, as well as the ‘diseases of modernity’—including pharmacological addiction, dementia, and ageing. Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders

Super Genes

Super Genes
  • Author : Deepak Chopra, M.D.,Rudolph E. Tanzi, Ph.D.
  • Publisher : Harmony
  • Release Date : 2015-11-10
  • ISBN : 9780804140140
DOWNLOAD BOOKSuper Genes

The authors of the New York Times bestseller Super Brain present a bold new understanding of our genes and how simple changes in lifestyle can boost genetic activity. The leap into "radical well-being" is a promise waiting to be fulfilled. "You are not simply the sum total of the genes you were born with," writes Deepak Chopra and Rudy Tanzi. "You are the user and controller of your genes, the author of your biological story. No prospect in self-care is

Post Traumatic Slave Syndrome

Post Traumatic Slave Syndrome
  • Author : Joy a Degruy
  • Publisher : Joy Degruy Publications Incorporated
  • Release Date : 2017-09-11
  • ISBN : 0985217278
DOWNLOAD BOOKPost Traumatic Slave Syndrome

In the 16th century, the beginning of African enslavement in the Americas until the ratification of the Thirteenth Amendment and emancipation in 1865, Africans were hunted like animals, captured, sold, tortured, and raped. They experienced the worst kind of physical, emotional, psychological, and spiritual abuse. Given such history, isn't it likely that many of the enslaved were severely traumatized? And did the trauma and the effects of such horrific abuse end with the abolition of slavery? Emancipation was followed by one

Handbook of Life Course Health Development

Handbook of Life Course Health Development
  • Author : Neal Halfon,Christopher B. Forrest,Richard M. Lerner,Elaine M. Faustman
  • Publisher : Springer
  • Release Date : 2017-11-20
  • ISBN : 9783319471433
DOWNLOAD BOOKHandbook of Life Course Health Development

This book is open access under a CC BY 4.0 license. ​This handbook synthesizes and analyzes the growing knowledge base on life course health development (LCHD) from the prenatal period through emerging adulthood, with implications for clinical practice and public health. It presents LCHD as an innovative field with a sound theoretical framework for understanding wellness and disease from a lifespan perspective, replacing previous medical, biopsychosocial, and early genomic models of health. Interdisciplinary chapters discuss major health concerns (diabetes, obesity), important

Medical Epigenetics

Medical Epigenetics
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2021-08-27
  • ISBN : 9780128243268
DOWNLOAD BOOKMedical Epigenetics

Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a broad spectrum of disease categories and specialties, and with a focus on human systems, epigenetic diseases that affect these systems, and evolving modes of epigenetic-based treatment. Here, more than 40 leading researchers examine how each human system is affected by epigenetic maladies, offering an all-in-one resource on medical epigenetics not only for those directly involved with health care, but investigators in life sciences, biotech companies, graduate

Pneumopedics And Craniofacial Epigenetics: Biomimetic Oral Appliance Therapy For Pediatric And Adult Sleep Disordered Breathing

Pneumopedics And Craniofacial Epigenetics: Biomimetic Oral Appliance Therapy For Pediatric And Adult Sleep Disordered Breathing
  • Author : G Dave Singh
  • Publisher : World Scientific
  • Release Date : 2021-03-05
  • ISBN : 9789811225369
DOWNLOAD BOOKPneumopedics And Craniofacial Epigenetics: Biomimetic Oral Appliance Therapy For Pediatric And Adult Sleep Disordered Breathing

This textbook provides a comprehensive introduction to the novel concepts of pneumopedics and craniofacial epigenetics. Clinically, these mechanisms are delivered through biomimetic oral appliance therapy. The text, therefore, covers both genetics and epigenetics of craniofacial development, as well as growth and development of the craniofacial architecture. Despite being complex subjects, the style of writing allows the general reader to assimilate this information and sets the scene for how these principles might best be utilized. For example, the clinical application of

Translational Pain Research

Translational Pain Research
  • Author : Lawrence Kruger,Alan R Light
  • Publisher : CRC Press
  • Release Date : 2009-11-24
  • ISBN : 9781439812105
DOWNLOAD BOOKTranslational Pain Research

One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone

An Introduction to Pain and its relation to Nervous System Disorders

An Introduction to Pain and its relation to Nervous System Disorders
  • Author : Anna A. Battaglia
  • Publisher : John Wiley & Sons
  • Release Date : 2016-03-02
  • ISBN : 9781118455937
DOWNLOAD BOOKAn Introduction to Pain and its relation to Nervous System Disorders

Introduction to Pain and its relation to Nervous System Disorders provides an accessible overview of the latest developments in the science underpinning pain research, including, but not limited to, the physiological, pathological and psychological aspects. This unique book fills a gap in current literature by focussing on the intricate relationship between pain and human nervous system disorders such as Autism, Alzheimer Disease, Parkinson’s Disease, Depression and Multiple Sclerosis. This fully illustrated, colour handbook will help non-experts, including advanced undergraduate