Drug Discovery Targeting Drug Resistant Bacteria

Book Drug Discovery Targeting Drug Resistant Bacteria Cover

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  • Publisher : Academic Press
  • Release : 15 May 2020
  • ISBN : 9780128184813
  • Page : 432 pages
  • Rating : 4.5/5 from 103 voters

Drug Discovery Targeting Drug Resistant Bacteria Book PDF summary

Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war

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Drug Discovery Targeting Drug-Resistant Bacteria

Drug Discovery Targeting Drug-Resistant Bacteria
  • Author : Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta
  • Publisher : Academic Press
  • Release Date : 2020-05-15
  • ISBN : 9780128184813
DOWNLOAD BOOKDrug Discovery Targeting Drug-Resistant Bacteria

Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules

Antibiotic Drug Discovery Targeting Bacterial Metabolism

Antibiotic Drug Discovery Targeting Bacterial Metabolism
  • Author : Miranda J Wallace
  • Publisher : Unknown
  • Release Date : 2019
  • ISBN : OCLC:1311596343
DOWNLOAD BOOKAntibiotic Drug Discovery Targeting Bacterial Metabolism

Over the last century, the use of antibiotics has enabled many advances in modern medicine, making life as we know it possible. In recent years, however, emerging bacterial resistance to virtually all major antibiotic classes has resulted in a worldwide increase in morbidity, mortality, and financial burden associated with drug resistant infections. The antimicrobial resistance crisis presents an urgent need for new antimicrobials with distinct mechanisms of action from existing drugs. The current pharmaceutical pipeline of new antibiotics is limited

Antibiotic Drug Discovery

Antibiotic Drug Discovery
  • Author : Steven M Firestine,Troy Lister
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-05-19
  • ISBN : 9781782629870
DOWNLOAD BOOKAntibiotic Drug Discovery

Recent years have seen a resurgence of antibiotic drug discovery. This book brings together the relevant information to assess the state-of-the-art. It identifies and elaborates the most recent and compelling strategies for antibiotic drug discovery with a primary focus on new targets, mechanisms and molecular entities. Addressing the need for continued investment in antibiotic drug development, the book provides a point of reference for the rapidly expanding infectious disease research community. In addition to its attention on new targets, the

Discovering Antibacterial and Anti-resistance Agents Targeting Multi-drug Resistant ESKAPE Pathogens

Discovering Antibacterial and Anti-resistance Agents Targeting Multi-drug Resistant ESKAPE Pathogens
  • Author : Renee Marie Fleeman
  • Publisher : Unknown
  • Release Date : 2017
  • ISBN : OCLC:1102390057
DOWNLOAD BOOKDiscovering Antibacterial and Anti-resistance Agents Targeting Multi-drug Resistant ESKAPE Pathogens

Antibiotic resistance has been a developing problem for mankind in recent decades and multi-drug resistant bacteria are now encountered that are resistant to all treatment options available. In 2014, the World Health Organization announced that this problem is driving us towards a “post-antibiotic era” that will change the face of modern medicine as we know it. If lack of novel antibiotic development and FDA approval continues, by the year 2050, 10 million people will die each year to an antimicrobial resistant bacterial infection.

Sustainable Agriculture Reviews 46

Sustainable Agriculture Reviews 46
  • Author : Harsh Panwar,Chetan Sharma,Eric Lichtfouse
  • Publisher : Unknown
  • Release Date : 2020
  • ISBN : 3030530264
DOWNLOAD BOOKSustainable Agriculture Reviews 46

According to the World Health Organization, antimicrobial resistance is a major threat to global health because the number of alternative antibiotics is very limited. Antimicrobial resistance is a slow evolutionary process that has been accelerated by human activities in health, environment and agriculture sectors. Due to their wide application, antibiotics and their residues have been found in almost all food products and natural ecosystems. This book reviews the drivers, impact and mitigation of antimicrobial resistance, with focus on methods and

Combination Therapy Against Multidrug Resistance

Combination Therapy Against Multidrug Resistance
  • Author : Mohmmad Younus Wani,Aijaz Ahmad
  • Publisher : Academic Press
  • Release Date : 2020-04-30
  • ISBN : 9780128205785
DOWNLOAD BOOKCombination Therapy Against Multidrug Resistance

Combination Therapy against Multidrug Resistance explores the potential of combination therapy as an efficient strategy to combat multi-drug resistance. Multidrug resistance (MDR) occurs when microorganisms such as bacteria, fungi, viruses, and parasites are excessively exposed to antimicrobial drugs such as antibiotics, antifungals, or antivirals, and in response the microorganism undergoes mutations or develops different resistance mechanisms to combat the drug for its survival. MDR is becoming an increasingly serious problem in both developed and developing nations. Bacterial resistance to antibiotics

Antibiotics and Bacterial Resistance

Antibiotics and Bacterial Resistance
  • Author : Wiley
  • Publisher : John Wiley & Sons
  • Release Date : 2013-01-14
  • ISBN : 9781118580912
DOWNLOAD BOOKAntibiotics and Bacterial Resistance

The need for novel antibiotics is greater now than perhaps anytime since the pre-antibiotic era. Indeed, the recent collapse ofmany pharmaceutical antibacterial groups, combined with theemergence of hypervirulent and pan-antibiotic-resistant bacteriahas severely compromised infection treatment options and led todramatic increases in the incidence and severity of bacterialinfections. This collection of reviews and laboratory protocols gives thereader an introduction to the causes of antibiotic resistance, thebacterial strains that pose the largest danger to humans (i.e.,streptococci, pneumococci and enterococci) and

Drug Discovery and Development

Drug Discovery and Development
  • Author : Omboon Vallisuta,Suleiman Olimat
  • Publisher : BoD – Books on Demand
  • Release Date : 2015-06-03
  • ISBN : 9789535121282
DOWNLOAD BOOKDrug Discovery and Development

It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against

New Antibiotic Targets

New Antibiotic Targets
  • Author : W. Scott Champney
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-01-15
  • ISBN : 9781588299154
DOWNLOAD BOOKNew Antibiotic Targets

This book examines specific techniques which can be used to explore new drug targets and the effectiveness of new antibiotics. By testing new antimicrobial agents and modified existing drugs, the most vulnerable cell processes, such as cell wall and membrane synthesis, DNA replication, RNA transcription and protein synthesis, can be better exploited. This in-depth volume, however, delves even deeper by identifying additional novel cellular targets for these new therapies. The book will provide laboratory investigators with the vital tools they

Make Antibiotics Great Again: Combating Drug Resistance by Targeting LexA, a Regulator of Bacterial Evolution

Make Antibiotics Great Again: Combating Drug Resistance by Targeting LexA, a Regulator of Bacterial Evolution
  • Author : Charlie Y. Mo
  • Publisher : Unknown
  • Release Date : 2016
  • ISBN : OCLC:982010069
DOWNLOAD BOOKMake Antibiotics Great Again: Combating Drug Resistance by Targeting LexA, a Regulator of Bacterial Evolution

The ability of bacterial pathogens to evolve and adapt to our antimicrobial agents has precipitated a global health crisis where treatment options for bacterial infections are running low. Recently, studies have shown that the ability to acquire resistance is linked to the SOS response, which is a widely conserved network of genes involved in both high fidelity and error-prone DNA damage repair. The SOS response is regulated by the DNA-binding protein, RecA, and a repressor-protease, LexA. When the cell experiences

Technological Challenges in Antibiotic Discovery and Development

Technological Challenges in Antibiotic Discovery and Development
  • Author : National Research Council,Division on Earth and Life Studies,Board on Chemical Sciences and Technology,Chemical Sciences Roundtable
  • Publisher : National Academies Press
  • Release Date : 2014-01-27
  • ISBN : 9780309298179
DOWNLOAD BOOKTechnological Challenges in Antibiotic Discovery and Development

Technological Challenges in Antibiotic Discovery and Development is the summary of a workshop convened by the Chemical Sciences Roundtable in September 2013 to explore the current state of antibiotic discovery and examine the technology available to facilitate development. Through formal presentations and panel discussions, participants from academia, industry, federal research agencies discussed the technical challenges present and the incentives and disincentives industry faces in antibiotic development, and identified novel approaches to antibiotic discovery. Antibiotic resistance is a serious and growing problem

Challenges to Tackling Antimicrobial Resistance Economic and Policy Responses

Challenges to Tackling Antimicrobial Resistance Economic and Policy Responses
  • Author : OECD,World Health Organization
  • Publisher : OECD Publishing
  • Release Date : 2020-04-01
  • ISBN : 9781108864121
DOWNLOAD BOOKChallenges to Tackling Antimicrobial Resistance Economic and Policy Responses

Antimicrobial resistance (AMR) is a biological mechanism whereby a microorganism evolves over time to develop the ability to become resistant to antimicrobial therapies such as antibiotics. The drivers of and potential solutions to AMR are complex, often spanning multiple sectors. The internationally recognized response to AMR advocates for a ‘One Health’ approach, which requires policies to be developed and implemented across human, animal, and environmental health.

Frontiers in Anti-Infective Drug Discovery

Frontiers in Anti-Infective Drug Discovery
  • Author : Atta-ur-Rahman,M. Iqbal Choudhary
  • Publisher : Bentham Science Publishers
  • Release Date : 2015-06-30
  • ISBN : 9781681080826
DOWNLOAD BOOKFrontiers in Anti-Infective Drug Discovery

This eBook series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the eBook series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials

Antibiotics

Antibiotics
  • Author : Claudio O. Gualerzi,Letizia Brandi,Attilio Fabbretti,Cynthia L. Pon
  • Publisher : John Wiley & Sons
  • Release Date : 2013-09-05
  • ISBN : 9783527659708
DOWNLOAD BOOKAntibiotics

Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel

Improving Food Safety Through a One Health Approach

Improving Food Safety Through a One Health Approach
  • Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
  • Publisher : National Academies Press
  • Release Date : 2012-10-10
  • ISBN : 9780309259330
DOWNLOAD BOOKImproving Food Safety Through a One Health Approach

Globalization of the food supply has created conditions favorable for the emergence, reemergence, and spread of food-borne pathogens-compounding the challenge of anticipating, detecting, and effectively responding to food-borne threats to health. In the United States, food-borne agents affect 1 out of 6 individuals and cause approximately 48 million illnesses, 128,000 hospitalizations, and 3,000 deaths each year. This figure likely represents just the tip of the iceberg, because it fails to account for the broad array of food-borne illnesses or for their wide-ranging repercussions for consumers,