Domino Reactions in Drug Discovery

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  • Publisher : Elsevier
  • Release : 01 October 2020
  • ISBN : 0128193743
  • Page : 315 pages
  • Rating : 4.5/5 from 103 voters

Domino Reactions in Drug Discovery Book PDF summary

Domino Reactions in Drug Discovery presents a concise selection of domino reactions employed in routes for the synthesis of pharmaceuticals, agrochemicals and the design of new drug candidates. These versatile reactions play an important and integral part in both the aesthetic appeal and functional aspects of strategic drug discovery, lending enhanced efficiency and synthetic versatility to pharmaceutical drug design. Due to their atom economy, these reactions are increasingly popular in the development of complex scaffolds and multifunctional derivatives aimed at the synthesis of new chemical entities and approved APIs across diverse therapeutic classes, including antidiabetics [DPP4 inhibitors], anticancer therapies and HIV integrase inhibitors. Features illustrated schemes with mechanisms, procedures and results Includes a compendium of Domino Name Reactions for drugs Provides a concise, comprehensive coverage of domino reactions in drug discovery, with a focus on sustainable practices

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Domino Reactions in Drug Discovery

Domino Reactions in Drug Discovery
  • Author : Shanta Bhar
  • Publisher : Elsevier
  • Release Date : 2020-10
  • ISBN : 0128193743
DOWNLOAD BOOKDomino Reactions in Drug Discovery

Domino Reactions in Drug Discovery presents a concise selection of domino reactions employed in routes for the synthesis of pharmaceuticals, agrochemicals and the design of new drug candidates. These versatile reactions play an important and integral part in both the aesthetic appeal and functional aspects of strategic drug discovery, lending enhanced efficiency and synthetic versatility to pharmaceutical drug design. Due to their atom economy, these reactions are increasingly popular in the development of complex scaffolds and multifunctional derivatives aimed at

Domino Reactions

Domino Reactions
  • Author : Lutz F. Tietze
  • Publisher : John Wiley & Sons
  • Release Date : 2013-12-23
  • ISBN : 9783527671328
DOWNLOAD BOOKDomino Reactions

The follow-up to the successful "Domino Reaction in Organic Synthesis", this ready reference brings up to date on the original concept. The chapters have been arranged according to the name of well-known transformations of the first step and in combination with the formed products. Each chapter is written by an internationally renowned expert, and the book is edited by L. F. Tietze, who established the concept of domino reactions. The one-stop source for all synthetic chemists to improve the synthetic

Synthesis of Aromatic Heterocycles by Palladium(0)-catalyzed Domino Reactions and Cyclization of Hydrazone Dianions

Synthesis of Aromatic Heterocycles by Palladium(0)-catalyzed Domino Reactions and Cyclization of Hydrazone Dianions
  • Author : Thang Ngoc Ngo
  • Publisher : Unknown
  • Release Date : 2016
  • ISBN : OCLC:968149399
DOWNLOAD BOOKSynthesis of Aromatic Heterocycles by Palladium(0)-catalyzed Domino Reactions and Cyclization of Hydrazone Dianions

Domino Reactions in Organic Synthesis

Domino Reactions in Organic Synthesis
  • Author : Lutz F. Tietze,Gordon Brasche,Kersten Gericke
  • Publisher : John Wiley & Sons
  • Release Date : 2006-12-13
  • ISBN : 9783527608683
DOWNLOAD BOOKDomino Reactions in Organic Synthesis

Domino reactions enable you to build complex structures in one-pot reactions without the need to isolate intermediates- a dream comes true. In this book, the well-respected expert, Professor Lutz Tietze, summarizes the possibilities of this reaction type - an approach for an efficiant, economically benificial and ecological benign synthesis. A definite must for every organic chemist.

Heterocyclic Chemistry in Drug Discovery

Heterocyclic Chemistry in Drug Discovery
  • Author : Jie Jack Li
  • Publisher : John Wiley & Sons
  • Release Date : 2013-04-26
  • ISBN : 9781118354438
DOWNLOAD BOOKHeterocyclic Chemistry in Drug Discovery

Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own

Multicomponent Reactions

Multicomponent Reactions
  • Author : Jieping Zhu,Hugues Bienaymé
  • Publisher : John Wiley & Sons
  • Release Date : 2006-03-06
  • ISBN : 9783527604241
DOWNLOAD BOOKMulticomponent Reactions

In the very first book on this hot topic, the expert editors andauthors present a comprehensive overview of these elegantreactions. From the contents: Organoboron compounds Free-radical mediated multicomponent coupling reactions Applications in drug discovery Metal catalyzed reactions Total synthesis of natural products Asymmetric isocyanide-based reactions The Biginelli reaction Asymmetric isocyanide-based reactions The Domino-Knoevenagel-Hetero-Diels-Alder Reaction and relatedtransformations Catalytic asymmetric reactions Algorithm based methods for discovering novel reactions Post-condensation modifications of the Passerini and Ugireactions An essential reference for organic and catalytic

Asymmetric Domino Reactions

Asymmetric Domino Reactions
  • Author : Helene Pellissier
  • Publisher : Royal Society of Chemistry
  • Release Date : 2013-03-13
  • ISBN : 9781849737104
DOWNLOAD BOOKAsymmetric Domino Reactions

This book covers the latest developments in asymmetric domino reactions, focussing on those published in the last 6 years. These fascinating reactions have rapidly become one of the most current fields in organic chemistry, since they allow reaching easily high molecular complexity in an economically favourable way with advantages of savings in solvent, time, energy, and costs. Unsurprisingly, the high levels of efficiency and enantioselectivity generally reached in these reactions have been exploited for the production of a wide number of

Diversity-Oriented Synthesis

Diversity-Oriented Synthesis
  • Author : Andrea Trabocchi
  • Publisher : John Wiley & Sons
  • Release Date : 2013-06-17
  • ISBN : 9781118618141
DOWNLOAD BOOKDiversity-Oriented Synthesis

Discover an enhanced synthetic approach to developing andscreening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developinglarge collections of structurally diverse small molecules as probesto investigate biological pathways. This book presents the mosteffective methods in diversity-oriented synthesis for creatingsmall molecule collections. It offers tested and proven strategiesfor developing diversity-oriented synthetic libraries and screeningmethods for identifying ligands. Lastly, it explores some promisingnew applications based on diversity-oriented synthesis that havethe potential to dramatically advance studies in drug discovery andchemical biology.

Privileged Structures in Drug Discovery

Privileged Structures in Drug Discovery
  • Author : Larry Yet
  • Publisher : John Wiley & Sons
  • Release Date : 2018-03-07
  • ISBN : 9781118686355
DOWNLOAD BOOKPrivileged Structures in Drug Discovery

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—

Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience

Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience
  • Author : Zbigniew J. Witczak,Roman Bielski
  • Publisher : John Wiley & Sons
  • Release Date : 2016-01-14
  • ISBN : 9781119044390
DOWNLOAD BOOKDomino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience

The book consists of a brief introduction, a foreward provided byprofessor Danishefsky of Columbia University, and about 14 –16 chapters, each written by one or two eminent scholars/authorsdescribing their recent research in the area of either dominoreactions or intramolecular rearrangements in carbohydratechemistry. Three or four chapters will be reviews. The domino (cascade, tandem)reactions are always intramolecular. They are usually very fast,clean and offer highly complex structures in a one pot process.Intramolecular rearrangements offer very similar advantages andoften lead

Small Molecule Drug Discovery

Small Molecule Drug Discovery
  • Author : Andrea Trabocchi,Elena Lenci
  • Publisher : Elsevier
  • Release Date : 2019-11-23
  • ISBN : 9780128183502
DOWNLOAD BOOKSmall Molecule Drug Discovery

Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The

Flow Chemistry in Drug Discovery

Flow Chemistry in Drug Discovery
  • Author : Jesus Alcazar
  • Publisher : Springer Nature
  • Release Date : 2022-08-13
  • ISBN : 9783030855925
DOWNLOAD BOOKFlow Chemistry in Drug Discovery

Synthesis of Heterocycles via Multicomponent Reactions II

Synthesis of Heterocycles via Multicomponent Reactions II
  • Author : Romano V. A. Orru,Eelco Ruijter
  • Publisher : Springer
  • Release Date : 2010-07-26
  • ISBN : 9783642154553
DOWNLOAD BOOKSynthesis of Heterocycles via Multicomponent Reactions II

Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric

Aromatic Polycyclic Hydrocarbons—Advances in Research and Application: 2013 Edition

Aromatic Polycyclic Hydrocarbons—Advances in Research and Application: 2013 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2013-06-21
  • ISBN : 9781481685269
DOWNLOAD BOOKAromatic Polycyclic Hydrocarbons—Advances in Research and Application: 2013 Edition

Aromatic Polycyclic Hydrocarbons—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Naphthalenes. The editors have built Aromatic Polycyclic Hydrocarbons—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Naphthalenes in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Aromatic Polycyclic Hydrocarbons—Advances in Research

Multicomponent Reactions

Multicomponent Reactions
  • Author : Raquel P. Herrera,Eugenia Marqués-López
  • Publisher : John Wiley & Sons
  • Release Date : 2015-03-30
  • ISBN : 9781118864005
DOWNLOAD BOOKMulticomponent Reactions

Addressing a dynamic aspect of organic chemistry, this bookdescribes synthetic strategies and applications for multicomponentreactions – including key routes for synthesizing complexmolecules. • Illustrates the crucial role and theimportant utility of multicomponent reactions (MCRs) to organicsyntheses • Compiles novel and efficient syntheticmulticomponent procedures to give readers a complete picture ofthis class of organic reactions • Helps readers to design efficient andpractical transformations using multicomponent reactionstrategies • Describes reaction background,applications to synthesize complex molecules and drugs, andreaction mechanisms