DNA Modifications in the Brain

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  • Publisher : Academic Press
  • Release : 23 December 2016
  • ISBN : 9780128017814
  • Page : 180 pages
  • Rating : 4.5/5 from 103 voters

DNA Modifications in the Brain Book PDF summary

DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease. Provides a comprehensive overview of the many facets of DNA modifications Discusses the impact of this dynamic epigenetic mechanism across brain development and lifespan at behavioral, cognitive, molecular and genetic levels Contains contributions by influential leaders in the field Edited by a Neuroscientist to further promote synthesis between epigenetics, neuroscience, and clinical relevance

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DNA Modifications in the Brain

DNA Modifications in the Brain
  • Author : Timothy W Bredy
  • Publisher : Academic Press
  • Release Date : 2016-12-23
  • ISBN : 9780128017814
DOWNLOAD BOOKDNA Modifications in the Brain

DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate

DNA Modifications

DNA Modifications
  • Author : Alexey Ruzov,Martin Gering
  • Publisher : Humana
  • Release Date : 2020-08-22
  • ISBN : 1071608754
DOWNLOAD BOOKDNA Modifications

This book provides an overview of methods and experimental protocols that are currently used to analyze the presence and abundance of non-canonical DNA nucleotides in different biological systems. Focusing particularly on the newly discovered and less studied DNA modifications that are enzymatically produced and are likely to play specific roles in various biological processes, the volume explores chromatography- and mass spectrometry-based techniques for the detection and quantification of DNA modifications, antibody-based approaches to study their spatial distribution in different cells

Epigenetics, Brain and Behavior

Epigenetics, Brain and Behavior
  • Author : Paolo Sassone Corsi,Yves Christen
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-10-19
  • ISBN : 9783642279133
DOWNLOAD BOOKEpigenetics, Brain and Behavior

Recent years have seen spectacular advances in the filed of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigentic regulation to brain functions has been accumulationg. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molcular mechanisms implicated in epigentic control and how these may operte in concert. It will be critical to unravel how specifity is achieved. The

The Epigenetics of Suicide

The Epigenetics of Suicide
  • Author : Benoit Labonté
  • Publisher : Unknown
  • Release Date : 2013
  • ISBN : OCLC:922058836
DOWNLOAD BOOKThe Epigenetics of Suicide

"Suicide is a problem resulting from the interaction between several factors. Among these factors, early-life adversity, characterized by child sexual and physical abuse as well as parental neglect, is one of the strongest risk factors for depression and suicidal behaviors. While it is clear that child abuse increases the risk for depression and suicide, the mechanisms mediating these effects are still unknown. Recent evidences suggest that epigenetic mechanisms may be involved in mediating the effects of early-life adversity on behavior.

The Neurobiological Basis of Suicide

The Neurobiological Basis of Suicide
  • Author : Yogesh Dwivedi
  • Publisher : CRC Press
  • Release Date : 2012-06-25
  • ISBN : 9781439838815
DOWNLOAD BOOKThe Neurobiological Basis of Suicide

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they

DNA Methylation and Complex Human Disease

DNA Methylation and Complex Human Disease
  • Author : Michel Neidhart
  • Publisher : Academic Press
  • Release Date : 2015-08-11
  • ISBN : 9780127999203
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DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as

Chromatin Signaling and Neurological Disorders

Chromatin Signaling and Neurological Disorders
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-05-24
  • ISBN : 9780128137970
DOWNLOAD BOOKChromatin Signaling and Neurological Disorders

Chromatin Signaling and Neurological Disorders, Volume Seven, explores our current understanding of how chromatin signaling regulates access to genetic information, and how their aberrant regulation can contribute to neurological disorders. Researchers, students and clinicians will not only gain a strong grounding on the relationship between chromatin signaling and neurological disorders, but they'll also discover approaches to better interpret and employ new diagnostic studies and epigenetic-based therapies. A diverse range of chapters from international experts speaks to the basis of chromatin

Epigenetics and Neuroplasticity - Evidence and Debate

Epigenetics and Neuroplasticity - Evidence and Debate
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2014-11-05
  • ISBN : 9780128010853
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The ‘epi-(Greek for ‘over’, ‘above’)genome’, with its rich cache of highly regulated, structural modifications—including DNA methylation, histone modifications and histone variants—defines the moldings and three-dimensional structures of the genomic material inside the cell nucleus and serves, literally, as a molecular bridge linking the environment to the genetic materials in our brain cells. Due to technological and scientific advances in the field, the field of neuroepigenetics is currently one of the hottest topics in the basic and

Epigenetics in Psychiatry

Epigenetics in Psychiatry
  • Author : Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos
  • Publisher : Academic Press
  • Release Date : 2021-08-16
  • ISBN : 9780128235782
DOWNLOAD BOOKEpigenetics in Psychiatry

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent

Epigenetic Epidemiology

Epigenetic Epidemiology
  • Author : Karin B. Michels
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-01-02
  • ISBN : 9789400724952
DOWNLOAD BOOKEpigenetic Epidemiology

The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the

Environmental Epigenetics

Environmental Epigenetics
  • Author : L. Joseph Su,Tung-chin Chiang
  • Publisher : Springer
  • Release Date : 2015-05-18
  • ISBN : 9781447166788
DOWNLOAD BOOKEnvironmental Epigenetics

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended

The DNA, RNA, and Histone Methylomes

The DNA, RNA, and Histone Methylomes
  • Author : Stefan Jurga,Jan Barciszewski
  • Publisher : Springer Nature
  • Release Date : 2019-08-28
  • ISBN : 9783030147921
DOWNLOAD BOOKThe DNA, RNA, and Histone Methylomes

This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions. Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom.

Neuroepigenomics in Aging and Disease

Neuroepigenomics in Aging and Disease
  • Author : Raul Delgado-Morales
  • Publisher : Springer
  • Release Date : 2017-05-18
  • ISBN : 9783319538891
DOWNLOAD BOOKNeuroepigenomics in Aging and Disease

Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes

Translational Research in Traumatic Brain Injury

Translational Research in Traumatic Brain Injury
  • Author : Daniel Laskowitz,Gerald Grant
  • Publisher : CRC Press
  • Release Date : 2015-12-01
  • ISBN : 9781498766579
DOWNLOAD BOOKTranslational Research in Traumatic Brain Injury

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps

The Effects of Sodium Butyrate (NaB) and Maltreatment Early in Postnatal Development on DNA Methylation in the Hippocampus and Amygdala of Adult Male Rats

The Effects of Sodium Butyrate (NaB) and Maltreatment Early in Postnatal Development on DNA Methylation in the Hippocampus and Amygdala of Adult Male Rats
  • Author : Isabella Archer
  • Publisher : Unknown
  • Release Date : 2019
  • ISBN : 1085636933
DOWNLOAD BOOKThe Effects of Sodium Butyrate (NaB) and Maltreatment Early in Postnatal Development on DNA Methylation in the Hippocampus and Amygdala of Adult Male Rats

Early life stress, especially childhood maltreatment, increases the risk for cognitive dysfunction and mental problems later in life. Studies have sought to identify how these phenotypes come about by examining structural and functional changes in various brain regions. Recent work has also focused on identifying whether changes in DNA methylation, an epigenetic modification that helps regulate gene transcription important for the structural and functional capacity of the brain, is also responsible for phenotypic outcomes. Using a rat model, we investigated