Deterministic Versus Stochastic Modelling in Biochemistry and Systems Biology

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  • Publisher : Elsevier
  • Release : 09 April 2013
  • ISBN : 9781908818218
  • Page : 390 pages
  • Rating : 4.5/5 from 103 voters

Deterministic Versus Stochastic Modelling in Biochemistry and Systems Biology Book PDF summary

Stochastic kinetic methods are currently considered to be the most realistic and elegant means of representing and simulating the dynamics of biochemical and biological networks. Deterministic versus stochastic modelling in biochemistry and systems biology introduces and critically reviews the deterministic and stochastic foundations of biochemical kinetics, covering applied stochastic process theory for application in the field of modelling and simulation of biological processes at the molecular scale. Following an overview of deterministic chemical kinetics and the stochastic approach to biochemical kinetics, the book goes onto discuss the specifics of stochastic simulation algorithms, modelling in systems biology and the structure of biochemical models. Later chapters cover reaction-diffusion systems, and provide an analysis of the Kinfer and BlenX software systems. The final chapter looks at simulation of ecodynamics and food web dynamics. Introduces mathematical concepts and formalisms of deterministic and stochastic modelling through clear and simple examples Presents recently developed discrete stochastic formalisms for modelling biological systems and processes Describes and applies stochastic simulation algorithms to implement a stochastic formulation of biochemical and biological kinetics

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Deterministic Versus Stochastic Modelling in Biochemistry and Systems Biology

Deterministic Versus Stochastic Modelling in Biochemistry and Systems Biology
  • Author : Paola Lecca,Ian Laurenzi,Ferenc Jordan
  • Publisher : Elsevier
  • Release Date : 2013-04-09
  • ISBN : 9781908818218
DOWNLOAD BOOKDeterministic Versus Stochastic Modelling in Biochemistry and Systems Biology

Stochastic kinetic methods are currently considered to be the most realistic and elegant means of representing and simulating the dynamics of biochemical and biological networks. Deterministic versus stochastic modelling in biochemistry and systems biology introduces and critically reviews the deterministic and stochastic foundations of biochemical kinetics, covering applied stochastic process theory for application in the field of modelling and simulation of biological processes at the molecular scale. Following an overview of deterministic chemical kinetics and the stochastic approach to biochemical

Identifiability and Regression Analysis of Biological Systems Models

Identifiability and Regression Analysis of Biological Systems Models
  • Author : Paola Lecca
  • Publisher : Springer Nature
  • Release Date : 2020-03-05
  • ISBN : 9783030412555
DOWNLOAD BOOKIdentifiability and Regression Analysis of Biological Systems Models

This richly illustrated book presents the objectives of, and the latest techniques for, the identifiability analysis and standard and robust regression analysis of complex dynamical models. The book first provides a definition of complexity in dynamic systems by introducing readers to the concepts of system size, density of interactions, stiff dynamics, and hybrid nature of determination. In turn, it presents the mathematical foundations of and algorithmic procedures for model structural and practical identifiability analysis, multilinear and non-linear regression analysis, and

Analysis of Biological Systems

Analysis of Biological Systems
  • Author : Corrado Priami,Melissa J Morine
  • Publisher : World Scientific
  • Release Date : 2015-01-29
  • ISBN : 9781783266890
DOWNLOAD BOOKAnalysis of Biological Systems

Modeling is fast becoming fundamental to understanding the processes that define biological systems. High-throughput technologies are producing increasing quantities of data that require an ever-expanding toolset for their effective analysis and interpretation. Analysis of high-throughput data in the context of a molecular interaction network is particularly informative as it has the potential to reveal the most relevant network modules with respect to a phenotype or biological process of interest. Analysis of Biological Systems collects classical material on analysis, modeling and

Theoretical Physics for Biological Systems

Theoretical Physics for Biological Systems
  • Author : Paola Lecca,Angela Re
  • Publisher : CRC Press
  • Release Date : 2019-01-30
  • ISBN : 9781351374323
DOWNLOAD BOOKTheoretical Physics for Biological Systems

Quantum physics provides the concepts and their mathematical formalization that lend themselves to describe important properties of biological networks topology, such as vulnerability to external stress and their dynamic response to changing physiological conditions. A theory of networks enhanced with mathematical concepts and tools of quantum physics opens a new area of biological physics, the one of systems biological physics.

Introduction to Modeling and Simulation with MATLAB® and Python

Introduction to Modeling and Simulation with MATLAB® and Python
  • Author : Steven I. Gordon,Brian Guilfoos
  • Publisher : CRC Press
  • Release Date : 2017-07-12
  • ISBN : 9781498773881
DOWNLOAD BOOKIntroduction to Modeling and Simulation with MATLAB® and Python

Introduction to Modeling and Simulation with MATLAB and Python is intended for students and professionals in science, social science, and engineering that wish to learn the principles of computer modeling, as well as basic programming skills. The book content focuses on meeting a set of basic modeling and simulation competencies that were developed as part of several National Science Foundation grants. Even though computer science students are much more expert programmers, they are not often given the opportunity to see

Phenotypic Switching

Phenotypic Switching
  • Author : Herbert Levine,Mohit Kumar Jolly,Prakash Kulkarni,Vidyanand Nanjundiah
  • Publisher : Academic Press
  • Release Date : 2020-06-10
  • ISBN : 9780128179970
DOWNLOAD BOOKPhenotypic Switching

Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance,

Bacterial Cellular Metabolic Systems

Bacterial Cellular Metabolic Systems
  • Author : K. Shimizu
  • Publisher : Elsevier
  • Release Date : 2013-03-26
  • ISBN : 9781908818201
DOWNLOAD BOOKBacterial Cellular Metabolic Systems

The metabolic regulation of a cell system is of critical importance in systems biology, and a robust model of these mechanisms is essential in predicting the effects on the metabolism of both the culture environment and the knockout of specific genes. Bacterial cellular metabolic systems focuses on this highly topical subject in relation to culture environment and provides a detailed analysis from gene level to metabolic level regulation, as well as offering a discussion of the most recent modelling approaches.

Dynamic Systems Biology Modeling and Simulation

Dynamic Systems Biology Modeling and Simulation
  • Author : Joseph DiStefano III
  • Publisher : Academic Press
  • Release Date : 2015-01-10
  • ISBN : 9780124104938
DOWNLOAD BOOKDynamic Systems Biology Modeling and Simulation

Dynamic Systems Biology Modeling and Simuation consolidates and unifies classical and contemporary multiscale methodologies for mathematical modeling and computer simulation of dynamic biological systems – from molecular/cellular, organ-system, on up to population levels. The book pedagogy is developed as a well-annotated, systematic tutorial – with clearly spelled-out and unified nomenclature – derived from the author’s own modeling efforts, publications and teaching over half a century. Ambiguities in some concepts and tools are clarified and others are rendered more accessible and practical.

Bioinformatics for Biomedical Science and Clinical Applications

Bioinformatics for Biomedical Science and Clinical Applications
  • Author : K-H Liang
  • Publisher : Elsevier
  • Release Date : 2013-07-31
  • ISBN : 9781908818232
DOWNLOAD BOOKBioinformatics for Biomedical Science and Clinical Applications

Contemporary biomedical and clinical research is undergoing constant development thanks to the rapid advancement of various high throughput technologies at the DNA, RNA and protein levels. These technologies can generate vast amounts of raw data, making bioinformatics methodologies essential in their use for basic biomedical and clinical applications. Bioinformatics for biomedical science and clinical applications demonstrates what these cutting-edge technologies can do and examines how to design an appropriate study, including how to deal with data and address specific clinical

Protein Folding in Silico

Protein Folding in Silico
  • Author : Irena Roterman-Konieczna
  • Publisher : Elsevier
  • Release Date : 2012-10-04
  • ISBN : 9781908818256
DOWNLOAD BOOKProtein Folding in Silico

Protein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction. Protein folding in silico approaches this issue by introducing an ab initio model that attempts to simulate as far as possible the folding process as it takes place in vivo, and attempts to construct a mechanistic model on the basis of the predictions made. The

Quality Assurance

Quality Assurance
  • Author : G Welty
  • Publisher : Elsevier
  • Release Date : 2013-06-30
  • ISBN : 9781908818621
DOWNLOAD BOOKQuality Assurance

Quality assurance is necessary to maintain quality and services in the pharmaceutical and life science industries. Quality assurance demonstrates that the logic and practice of problem solving can integrate both program efficacy and regulatory compliance. This title is divided into three parts; the first part discusses the process by which a problem in regulated industry is identified, for example a manufacturing deviation that leads to an adulterated drug product, and reviews the decision-making steps involved in remedying the problem. The

An Introduction to Pharmaceutical Sciences

An Introduction to Pharmaceutical Sciences
  • Author : Jiben Roy
  • Publisher : Elsevier
  • Release Date : 2011-07-25
  • ISBN : 9781908818041
DOWNLOAD BOOKAn Introduction to Pharmaceutical Sciences

This textbook is written as a unified approach to various topics, ranging from drug discovery to manufacturing, techniques and technology, regulation and marketing. The key theme of the book is pharmaceuticals - what every student of pharmaceutical sciences should know: from the active pharmaceutical ingredients to the preparation of various dosage forms along with the relevant chemistry, this book makes pharmaceuticals relevant to undergraduate students of pharmacy and pharmaceutical sciences. This book explains how a particular drug was discovered and

Allergens and Respiratory Pollutants

Allergens and Respiratory Pollutants
  • Author : Marc A. Williams
  • Publisher : Elsevier
  • Release Date : 2011-07-18
  • ISBN : 9781908818065
DOWNLOAD BOOKAllergens and Respiratory Pollutants

Allergens and respiratory pollutants is a collection of 12 authoritative papers that draws upon the collective expertise of world leaders in the fields of innate immunity, immunotoxicology and pulmonary biology. The book critically explores the biological and immunological mechanisms that contribute to immune dysfunction on exposure to allergens and the susceptibility to infectious disease on exposure to ambient pollutants. The clinical relevance of exposure to ambient airborne xenobiotics is critically discussed and collectively, this book provides an educational forum that links

Annotating New Genes

Annotating New Genes
  • Author : Shizuka Uchida
  • Publisher : Elsevier
  • Release Date : 2012-08-06
  • ISBN : 9781908818126
DOWNLOAD BOOKAnnotating New Genes

In recent years, a number of academic and commercial software packages and databases have been developed for the analysis and screening of biological data; however, the usability of these data is compromised by so-called novel genes to which no biological function is assigned. Annotating new genes outlines an approach to the analysis of evolutionary-conserved, heart-enriched genes with unknown functions, offering a step-by-step description of the procedure from screening to validation. The book begins by offering an introduction to the databases

Computer-Aided Vaccine Design

Computer-Aided Vaccine Design
  • Author : Joo Chuan Tong,Shoba Ranganathan
  • Publisher : Elsevier
  • Release Date : 2013-07-31
  • ISBN : 9781908818416
DOWNLOAD BOOKComputer-Aided Vaccine Design

Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates. Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used,