Computational Non coding RNA Biology

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  • Publisher : Academic Press
  • Release : 14 September 2018
  • ISBN : 9780128143667
  • Page : 320 pages
  • Rating : 4.5/5 from 103 voters

Computational Non coding RNA Biology Book PDF summary

Computational Non-coding RNA Biology is a resource for the computation of non-coding RNAs. The book covers computational methods for the identification and quantification of non-coding RNAs, including miRNAs, tasiRNAs, phasiRNAs, lariat originated circRNAs and back-spliced circRNAs, the identification of miRNA/siRNA targets, and the identification of mutations and editing sites in miRNAs. The book introduces basic ideas of computational methods, along with their detailed computational steps, a critical component in the development of high throughput sequencing technologies for identifying different classes of non-coding RNAs and predicting the possible functions of these molecules. Finding, quantifying, and visualizing non-coding RNAs from high throughput sequencing datasets at high volume is complex. Therefore, it is usually possible for biologists to complete all of the necessary steps for analysis. Presents a comprehensive resource of computational methods for the identification and quantification of non-coding RNAs Introduces 23 practical computational pipelines for various topics of non-coding RNAs Provides a guide to assist biologists and other researchers dealing with complex datasets Introduces basic computational methods and provides guidelines for their replication by researchers Offers a solution to researchers approaching large and complex sequencing datasets

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Computational Non-coding RNA Biology

Computational Non-coding RNA Biology
  • Author : Yun Zheng
  • Publisher : Academic Press
  • Release Date : 2018-09-14
  • ISBN : 9780128143667
DOWNLOAD BOOKComputational Non-coding RNA Biology

Computational Non-coding RNA Biology is a resource for the computation of non-coding RNAs. The book covers computational methods for the identification and quantification of non-coding RNAs, including miRNAs, tasiRNAs, phasiRNAs, lariat originated circRNAs and back-spliced circRNAs, the identification of miRNA/siRNA targets, and the identification of mutations and editing sites in miRNAs. The book introduces basic ideas of computational methods, along with their detailed computational steps, a critical component in the development of high throughput sequencing technologies for identifying different

Computational Biology of Non-Coding RNA

Computational Biology of Non-Coding RNA
  • Author : Xin Lai,Shailendra K. Gupta,Julio Vera
  • Publisher : Humana Press
  • Release Date : 2019-02-04
  • ISBN : 1493989812
DOWNLOAD BOOKComputational Biology of Non-Coding RNA

This volume details a collection of state-of-art methods including identification of novel ncRNAs and their targets, functional annotation and disease association in different biological contexts. Chapters guide readers through an overview of disease-specific ncRNAs, computational methods and workflows for ncRNA discovery, annotation based on high-throughput sequencing data, bioinformatics tools and databases for ncRNA analyses, network-based methods, and kinetic modelling of ncRNA-mediated gene regulation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective

Long Noncoding RNAs in Plants

Long Noncoding RNAs in Plants
  • Author : Santosh Kumar Upadhyay
  • Publisher : Academic Press
  • Release Date : 2020-11-13
  • ISBN : 9780128214633
DOWNLOAD BOOKLong Noncoding RNAs in Plants

The growth of human population has increased the demand for improved yield and quality of crops and horticultural plants. However, plant productivity continues to be threatened by stresses such as heat, cold, drought, heavy metals, UV radiations, bacterial and fungal pathogens, and insect pests. Long noncoding RNAs are associated with various developmental pathways, regulatory systems, abiotic and biotic stress responses and signaling, and can provide an alternative strategy for stress management in plants. Long Noncoding RNAs in Plants: Roles in

Cancer and Noncoding RNAs

Cancer and Noncoding RNAs
  • Author : Jayprokas Chakrabarti,Sanga Mitra
  • Publisher : Academic Press
  • Release Date : 2017-10-13
  • ISBN : 9780128134375
DOWNLOAD BOOKCancer and Noncoding RNAs

Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail

Computational Methods for Genome-wide Non-coding RNA Discovery and Analysis

Computational Methods for Genome-wide Non-coding RNA Discovery and Analysis
  • Author : Shaojie Zhang
  • Publisher : Unknown
  • Release Date : 2007
  • ISBN : OCLC:180189876
DOWNLOAD BOOKComputational Methods for Genome-wide Non-coding RNA Discovery and Analysis

The discovery of novel non-coding RNAs has been among the most exciting recent developments in Biology, yet, many more remain undiscovered. It has been hypothesized that there is in fact an abundance of functional non-coding RNAs (ncRNAs) with various catalytic and regulatory functions. Computational methods tailored specifically for ncRNA discovery are being actively developed. As the inherent signal for ncRNA is weaker than that for protein coding genes, comparative methods offer the most promising approach. In this dissertation, we address

Long Non-Coding Rnas: Methods and Protocols

Long Non-Coding Rnas: Methods and Protocols
  • Author : Yi Feng,Lin Zhang
  • Publisher : Methods in Molecular Biology
  • Release Date : 2018-04-15
  • ISBN : 1493980351
DOWNLOAD BOOKLong Non-Coding Rnas: Methods and Protocols

This volume assembles a broad spectrum of methods used in long non-coding RNAs (lncRNA) research, ranging from computational annotation of lncRNA genes to molecular and cellular analyses of the function of individual lncRNA. Long Non-Coding RNAs: Methods and Protocols also discusses methods used to study circular RNAs and RNA splicing, as well as influential findings on lncRNA in human diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of

Small Non-Coding RNAs

Small Non-Coding RNAs
  • Author : Mathieu Rederstorff
  • Publisher : Humana Press
  • Release Date : 2015-03-21
  • ISBN : 1493925466
DOWNLOAD BOOKSmall Non-Coding RNAs

This volume contains state-of-the-art methods tackling all aspects of small non-coding RNAs biology. Small Non-Coding RNAs: Methods and Protocols guides readers through customized dedicated protocols and technologies that will be of valuable help to all those willing to contribute deciphering the numerous functions of small non-coding RNAs. Written in the highly successful Methods of Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips

Gene Expression Profiling in Cancer

Gene Expression Profiling in Cancer
  • Author : Dimitrios Vlachakis
  • Publisher : BoD – Books on Demand
  • Release Date : 2019-06-19
  • ISBN : 9781838801755
DOWNLOAD BOOKGene Expression Profiling in Cancer

The contribution of modern-day genetics in designing efficient gene expression profiles for cancer is immense. The progress of technology and science in recent years provides the opportunity for discovery and application of new techniques for treating various diseases that affect humanity. Methods for finding and analyzing the profile of gene expression of infected cells give scientists the ability to develop more targeted and effective treatments, especially for diseases such as cancer. The development of gene expression profiling is one of

RNA-Based Regulation in Human Health and Disease

RNA-Based Regulation in Human Health and Disease
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-08-19
  • ISBN : 9780128171943
DOWNLOAD BOOKRNA-Based Regulation in Human Health and Disease

RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA

Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges

Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges
  • Author : Carlo Maria Croce,Alfredo Ferro,Alessandro Laganà
  • Publisher : Frontiers Media SA
  • Release Date : 2017-01-27
  • ISBN : 9782889450961
DOWNLOAD BOOKBioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges

The recent discovery of small and long non-coding RNAs (ncRNAs) has represented a major breakthrough in the life sciences. These molecules add a new layer of complexity to biological processes and pathways by revealing a sophisticated and dynamic interconnected system whose structure is just beginning to be uncovered. Genetic and epigenetic aberrations affecting ncRNA gene sequences and their expression have been linked to a variety of pathological conditions, including cancer, cardiovascular and neurological diseases. Latest advances in the development of

Long Non Coding RNA Biology

Long Non Coding RNA Biology
  • Author : M.R.S. Rao
  • Publisher : Springer
  • Release Date : 2017-08-16
  • ISBN : 9789811052033
DOWNLOAD BOOKLong Non Coding RNA Biology

This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.

Long Non-Coding RNAs in Cancer

Long Non-Coding RNAs in Cancer
  • Author : Alfons Navarro
  • Publisher : Unknown
  • Release Date : 2021
  • ISBN : 1071615815
DOWNLOAD BOOKLong Non-Coding RNAs in Cancer

This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery

The Chemical Biology of Long Noncoding RNAs

The Chemical Biology of Long Noncoding RNAs
  • Author : Stefan Jurga,Jan Barciszewski
  • Publisher : Springer Nature
  • Release Date : 2020-10-01
  • ISBN : 9783030447434
DOWNLOAD BOOKThe Chemical Biology of Long Noncoding RNAs

This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A

RNA Bioinformatics

RNA Bioinformatics
  • Author : Ernesto Picardi
  • Publisher : Humana Press
  • Release Date : 2015-01-11
  • ISBN : 1493922904
DOWNLOAD BOOKRNA Bioinformatics

This volume provides an overview of RNA bioinformatics methodologies, including basic strategies to predict secondary and tertiary structures, and novel algorithms based on massive RNA sequencing. Interest in RNA bioinformatics has rapidly increased thanks to the recent high-throughput sequencing technologies allowing scientists to investigate complete transcriptomes at single nucleotide resolution. Adopting advanced computational technics, scientists are now able to conduct more in-depth studies and present them to you in this book. Written in the highly successful Methods of Molecular Biology

Non-coding RNAs in Cardiovascular Diseases

Non-coding RNAs in Cardiovascular Diseases
  • Author : Junjie Xiao
  • Publisher : Springer Nature
  • Release Date : 2020-04-13
  • ISBN : 9789811516719
DOWNLOAD BOOKNon-coding RNAs in Cardiovascular Diseases

This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide. Non-coding RNAs play a significant role in development, proliferation, differentiation and apoptosis. Since altered non-coding RNA expression is often associated with various diseases, their potential use in diagnostics, prognostics and therapeutics is an important current area of study. The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding