Cellular and Animal Models in Human Genomics Research

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  • Publisher : Academic Press
  • Release : 30 July 2019
  • ISBN : 9780128165744
  • Page : 226 pages
  • Rating : 4.5/5 from 103 voters

Cellular and Animal Models in Human Genomics Research Book PDF summary

Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms

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Cellular and Animal Models in Human Genomics Research

Cellular and Animal Models in Human Genomics Research
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-07-30
  • ISBN : 9780128165744
DOWNLOAD BOOKCellular and Animal Models in Human Genomics Research

Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : P. Michael Conn
  • Publisher : Academic Press
  • Release Date : 2013-05-29
  • ISBN : 9780124159129
DOWNLOAD BOOKAnimal Models for the Study of Human Disease

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders,

Advances in Animal Genomics

Advances in Animal Genomics
  • Author : Sukanta Mondal,Ram Lakhan Singh
  • Publisher : Academic Press
  • Release Date : 2020-11-25
  • ISBN : 9780128206126
DOWNLOAD BOOKAdvances in Animal Genomics

Advances in Animal Genomics provides an outstanding collection of integrated strategies involving traditional and modern - omics (structural, functional, comparative and epigenomics) approaches and genomics-assisted breeding methods which animal biotechnologists can utilize to dissect and decode the molecular and gene regulatory networks involved in the complex quantitative yield and stress tolerance traits in livestock. Written by international experts on animal genomics, this book explores the recent advances in high-throughput, next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics

Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery
  • Author : Asfar Azmi,Ramzi M. Mohammad
  • Publisher : Academic Press
  • Release Date : 2019-04-16
  • ISBN : 9780128147054
DOWNLOAD BOOKAnimal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized

The Mouse in Animal Genetics and Breeding Research

The Mouse in Animal Genetics and Breeding Research
  • Author : Eugene J. Eisen
  • Publisher : World Scientific
  • Release Date : 2005
  • ISBN : 9781860945656
DOWNLOAD BOOKThe Mouse in Animal Genetics and Breeding Research

The sequencing of the mouse genome has placed the mouse front and center as the most important mammalian genetics model. However, no recent volume has detailed the genetic contributions the mouse has made across the spectrum of the life sciences; this book aims to fill that vacuum. Mouse genetics research has made enormous contributions to the understanding of basic genetics, human genetics, and livestock genetics and breeding. The wide-ranging topics in the book include the mouse genome sequencing effort, molecular

What Will We Do If We Don't Experiment on Animals?

What Will We Do If We Don't Experiment on Animals?
  • Author : Jean Swingle Greek,C. Ray Greek
  • Publisher : Trafford Publishing
  • Release Date : 2004
  • ISBN : 9781412020589
DOWNLOAD BOOKWhat Will We Do If We Don't Experiment on Animals?

Drs. Greek have written 2 books on why using animals as models for humans is not the best way to conduct medical research and drug testing. During their lectures and debates, the most commonly asked question was, "Well. What will we use if we don't use animals?" What Will We Do If We Don't Experiment On Animals? Medical Research for the Twenty-first Century is the answer to that question. Drs. Greek explain briefly why one species cannot predict drug response for

Animal Biotechnology

Animal Biotechnology
  • Author : Ashish S. Verma,Anchal Singh
  • Publisher : Academic Press
  • Release Date : 2020-06-11
  • ISBN : 9780128117255
DOWNLOAD BOOKAnimal Biotechnology

Animal Biotechnology: Models in Discovery and Translation, Second Edition, provides a helpful guide to anyone seeking a thorough review of animal biotechnology and its application to human disease and welfare. This updated edition covers vital fundamentals, including animal cell cultures, genome sequencing analysis, epigenetics and animal models, gene expression, and ethics and safety concerns, along with in-depth examples of implications for human health and prospects for the future. New chapters cover animal biotechnology as applied to various disease types and

Exploring the Biological Contributions to Human Health

Exploring the Biological Contributions to Human Health
  • Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Understanding the Biology of Sex and Gender Differences
  • Publisher : National Academies Press
  • Release Date : 2001-07-02
  • ISBN : 0309132975
DOWNLOAD BOOKExploring the Biological Contributions to Human Health

It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be

Animal Models of Speech and Language Disorders

Animal Models of Speech and Language Disorders
  • Author : Santosh A. Helekar
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-10-17
  • ISBN : 9781461484004
DOWNLOAD BOOKAnimal Models of Speech and Language Disorders

Basic research over the last decade or two has uncovered similarities between speech, especially its sensori-motor aspects, and vocal communication in several non-human species. The most comprehensive studies so far have been conducted in songbirds. Songbirds offer us a model system to study the interactions between developmental or genetic predispositions and tutor-dependent influences, on the learning of vocal communication. Songbird research has elucidated cellular and molecular mechanisms underlying learning and production of vocal patterns, perception of vocal sounds, vocal motor

Use of Laboratory Animals in Biomedical and Behavioral Research

Use of Laboratory Animals in Biomedical and Behavioral Research
  • Author : National Research Council,Institute of Medicine,Institute for Laboratory Animal Research,Commission on Life Sciences,Committee on the Use of Laboratory Animals in Biomedical and Behavioral Research
  • Publisher : National Academies Press
  • Release Date : 1988-02-01
  • ISBN : 9780309038393
DOWNLOAD BOOKUse of Laboratory Animals in Biomedical and Behavioral Research

Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of

Heritable Human Genome Editing

Heritable Human Genome Editing
  • Author : The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
  • Publisher : National Academies Press
  • Release Date : 2021-01-16
  • ISBN : 9780309671132
DOWNLOAD BOOKHeritable Human Genome Editing

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing

Linking Phenotypes and Genotypes

Linking Phenotypes and Genotypes
  • Author : Florian Markowetz,Michael Boutros
  • Publisher : Cambridge University Press
  • Release Date : 2015-07-02
  • ISBN : 9781107013841
DOWNLOAD BOOKLinking Phenotypes and Genotypes

The first book to comprehensively cover the field of systems genetics, gathering contributions from leading scientists.

Functional Analysis of the Human Genome

Functional Analysis of the Human Genome
  • Author : F. Farzaneh,D. N. Cooper
  • Publisher : Garland Science
  • Release Date : 2020-09-11
  • ISBN : 9781000140965
DOWNLOAD BOOKFunctional Analysis of the Human Genome

An excellent review of the relationship between structure and function in the human genome, and a detailed description of some of the important methodologies for unravelling the function of genes and genomic structures.

Genomics and Personalized Medicine

Genomics and Personalized Medicine
  • Author : Michael Snyder
  • Publisher : Oxford University Press
  • Release Date : 2016-02-09
  • ISBN : 9780190234782
DOWNLOAD BOOKGenomics and Personalized Medicine

In 2001 the Human Genome Project succeeded in mapping the DNA of humans. This landmark accomplishment launched the field of genomics, the integrated study of all the genes in the human body and the related biomedical interventions that can be tailored to benefit a person's health. Today genomics, part of a larger movement toward personalized medicine, is poised to revolutionize health care. By cross-referencing an individual's genetic sequence -- their genome -- against known elements of "Big Data," elements of genomics

Handbook of Laboratory Animal Science, Volume I, Third Edition

Handbook of Laboratory Animal Science, Volume I, Third Edition
  • Author : Jann Hau,Steven J. Schapiro
  • Publisher : CRC Press
  • Release Date : 2010-12-02
  • ISBN : 1420084550
DOWNLOAD BOOKHandbook of Laboratory Animal Science, Volume I, Third Edition

Laboratory animal testing provides most of our current knowledge of human physiology, microbiology, immunology, pharmacology, and pathology. From studies of genetics in fruit flies to studies of cellular processes in genetically modified mice to recent dramatic developments in genetics, translational research, and personalized medicines, biomedical research involving animals remains absolutely essential for the advancement of the medical, veterinary, agricultural, and biological sciences and all rely on access to high-quality laboratory animals as models for humans. Rooted in the principle that