Biometals in Neurodegenerative Diseases

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  • Publisher : Academic Press
  • Release : 28 April 2017
  • ISBN : 9780128045633
  • Page : 462 pages
  • Rating : 4.5/5 from 103 voters

Biometals in Neurodegenerative Diseases Book PDF summary

Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer’s Disease, Parkinson’s Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases. Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics. Authoritative and timely resource bringing together the major findings in the field for those with an interest in metals and their role in the brain function, disease, and as therapeutic targets Written for academic researchers, clinicians and advanced graduate students studying, or treating, patients in neurodegeneration, neurochemistry, neurology and neurotoxicology Edited by international leaders in the field who have contributed greatly to the study of metals in neurodegenerative diseases

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Biometals in Neurodegenerative Diseases

Biometals in Neurodegenerative Diseases
  • Author : Anthony R. White,Michael Aschner,Lucio G. Costa,Ashley I. Bush
  • Publisher : Academic Press
  • Release Date : 2017-04-28
  • ISBN : 9780128045633
DOWNLOAD BOOKBiometals in Neurodegenerative Diseases

Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer’s Disease, Parkinson’s Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. This book is written for academic researchers, clinicians and advanced graduate students studying or

Metals and Neurodegeneration: Restoring the Balance

Metals and Neurodegeneration: Restoring the Balance
  • Author : Anthony R. White,Katja M. Kanninen,Peter J. Crouch
  • Publisher : Frontiers Media SA
  • Release Date : 2016-02-02
  • ISBN : 9782889197392
DOWNLOAD BOOKMetals and Neurodegeneration: Restoring the Balance

Biometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism can lead to detrimental effects on cell function and survival. These biometals have important roles in the brain, driving cellular respiration, antioxidant activity, intracellular signaling and many additional structural and enzymatic functions. There is now considerable evidence that abnormal biometal homeostasis is a key feature of many neurodegenerative diseases and may have an important role in the onset and progression of disorders such as Alzheimer’s,

Investigating the Mechanistic Link Between Neuroinflammation and Biometal Homeostasis in Neurodegenerative Diseases

Investigating the Mechanistic Link Between Neuroinflammation and Biometal Homeostasis in Neurodegenerative Diseases
  • Author : Lobna Alukaidey
  • Publisher : Unknown
  • Release Date : 2015
  • ISBN : OCLC:990045094
DOWNLOAD BOOKInvestigating the Mechanistic Link Between Neuroinflammation and Biometal Homeostasis in Neurodegenerative Diseases

Metal-Based Neurodegeneration

Metal-Based Neurodegeneration
  • Author : Robert Crichton,Roberta Ward
  • Publisher : John Wiley & Sons
  • Release Date : 2013-09-04
  • ISBN : 9781118553510
DOWNLOAD BOOKMetal-Based Neurodegeneration

Neurodegenerative diseases of the human brain appear in variousforms, resulting in disorders of movement and coordination,cognitive deterioration and psychiatric disturbances. Many of thekey factors leading to neurodegenerative diseases are similar,including the dysfunction of metal ion homeostasis, redox-activemetal ions generating oxidative stress, and intracellular inclusionbodies. Metal-based Neurodegeneration presents a detailed surveyof the molecular origins of neurodegenerative diseases. Eachchapter is dedicated to a specific disease, presenting the latestscientific findings, including details of their biochemicalactors (proteins or peptides), their normal and

Metal Related Neurodegenerative Disease

Metal Related Neurodegenerative Disease
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2013-11-07
  • ISBN : 9780124105355
DOWNLOAD BOOKMetal Related Neurodegenerative Disease

This issue reviews the role of metals in neurodegenerative diseases; including Parkinson’s and Huntington’s disease; restless leg syndrome and NBIA disorders; and Wilson’s disease and manganese and calcium accumulation disorders. An update on advances in neuroimaging and pathology of metal related disease is also presented. This volume of International Review of Neurobiology brings together cutting-edge research on metal related neurodegenerative disease It reviews the role of metals in neurodegenerative diseases, including Parkinson’s and Huntington’s disease;

Nervous System Diseases—Advances in Research and Treatment: 2013 Edition

Nervous System Diseases—Advances in Research and Treatment: 2013 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2013-06-21
  • ISBN : 9781481678001
DOWNLOAD BOOKNervous System Diseases—Advances in Research and Treatment: 2013 Edition

Nervous System Diseases—Advances in Research and Treatment: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Neuromuscular Diseases. The editors have built Nervous System Diseases—Advances in Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuromuscular Diseases in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nervous System Diseases—Advances

Combustion Emissions

Combustion Emissions
  • Author : Keith Schofield
  • Publisher : Academic Press
  • Release Date : 2020-01-10
  • ISBN : 9780128191279
DOWNLOAD BOOKCombustion Emissions

Combustion Emissions: Formation, Reaction, and Removal of Trace Metals in Combustion Products presents the latest scientific knowledge on combustion, with a particular focus on the behavior of elements in this high temperature method of energy generation. The book describes methods of control and establishes a solid base of understanding for future research. Encyclopedic in style and consistent in format, each chapter systematically presents a complete analysis of the combustion behavior of each element and guides the reader in resolving specific

Frontiers in Clinical Drug Research - Dementia: Volume 1

Frontiers in Clinical Drug Research - Dementia: Volume 1
  • Author : Atta-ur-Rahman
  • Publisher : Bentham Science Publishers
  • Release Date : 2020-06-02
  • ISBN : 9789811410932
DOWNLOAD BOOKFrontiers in Clinical Drug Research - Dementia: Volume 1

Frontiers in Clinical Drug Research - Dementia is a book series which presents comprehensive reviews about research on Dementia, - the loss of brain function associated with Alzheimer’s disease and other related medical conditions. The disease affects the parts of the brain that deal with memory, thought, and language. Chapters in each volume focus on drug research with special emphasis on clinical trials, research on drugs in advanced stages of development and cure for dementia and related disorders. This

Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America

Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America
  • Author : Agustín Ibáñez,Lucas Sedeño,Adolfo M. García,Robert M.J. Deacon,Patricia Cogram
  • Publisher : Frontiers Media SA
  • Release Date : 2018-06-21
  • ISBN : 9782889454945
DOWNLOAD BOOKHuman and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America

Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and

Biometal-induced Structural Consequences of [alpha]-synuclein - the Parkinson's Disease Protein

Biometal-induced Structural Consequences of [alpha]-synuclein - the Parkinson's Disease Protein
  • Author : Dinendra L. Abeyawardhane
  • Publisher : Unknown
  • Release Date : 2019
  • ISBN : OCLC:1105930713
DOWNLOAD BOOKBiometal-induced Structural Consequences of [alpha]-synuclein - the Parkinson's Disease Protein

The pre-synaptic protein [alpha]-Synuclein ([alpha]S) is often linked to the pathology of Parkinson's disease (PD), an age-related neurodegenerative disorder. Lewy bodies, the cytopathological hallmarks of PD, are found to be rich in aggregates of misfolded [alpha]S protein. Metal dyshomeostasis has also been linked to PD due to the accumulation of iron in the substantia nigra pars compacta, and diminished copper levels reported in this same region. Metal dyshomeostasis in the brain coupled with oxidative stress can enhance

Connections to Membrane Trafficking Where You Least Expect Them: Diseases, Dynamics, Diet and Distance

Connections to Membrane Trafficking Where You Least Expect Them: Diseases, Dynamics, Diet and Distance
  • Author : Rachel Susan Kraut,Guillaume Thibault,Sarita Hebbar,Elisabeth Knust
  • Publisher : Frontiers Media SA
  • Release Date : 2020-01-28
  • ISBN : 9782889634293
DOWNLOAD BOOKConnections to Membrane Trafficking Where You Least Expect Them: Diseases, Dynamics, Diet and Distance

Protein Misfolding, Aggregation and Conformational Diseases

Protein Misfolding, Aggregation and Conformational Diseases
  • Author : Vladimir N. Uversky,Anthony Fink
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-05-26
  • ISBN : 9780387365343
DOWNLOAD BOOKProtein Misfolding, Aggregation and Conformational Diseases

The second volume continues to fill the gap in protein review and protocol literature. It does this while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders.

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases
  • Author : Akhlaq A. Farooqui
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-09-02
  • ISBN : 9781441966520
DOWNLOAD BOOKNeurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases

Collectively, neurodegenerative diseases are characterized by chronic and progressive loss of neurons in discrete areas of the brain, producing debilitating symptoms such as dementia, loss of memory, loss of sensory or motor capability, decreased overall quality of life eventually leading to premature death. Two types of cell death are known to occur during neurodegeneration: (a) apoptosis and (b) necrosis. The necrosis is characterized by the passive cell swelling, intense mitochondrial damage with rapid loss of ATP, alterations in neural membrane

Antioxidants and Functional Foods for Neurodegenerative Disorders

Antioxidants and Functional Foods for Neurodegenerative Disorders
  • Author : Abhai Kumar,Debasis Bagchi
  • Publisher : CRC Press
  • Release Date : 2021-01-07
  • ISBN : 9781000282740
DOWNLOAD BOOKAntioxidants and Functional Foods for Neurodegenerative Disorders

Neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are a growing problem across the world’s aging population. Oxidative stress in the brain plays a central role in a common pathophysiology of these diseases. This book presents scientific research on the potential of antioxidant therapy in the prevention and treatment of neurodegenerative disorders. This book outlines the roles of oxidative stress and diabetes mellitus in neurodegeneration, describes the molecular mechanisms of neurodegenerative disorders including the roles of environmental pollutants

Oxidative Stress and Neurodegenerative Disorders

Oxidative Stress and Neurodegenerative Disorders
  • Author : G. Ali Qureshi,S. Hasan Parvez
  • Publisher : Elsevier
  • Release Date : 2007-03-22
  • ISBN : 0080489494
DOWNLOAD BOOKOxidative Stress and Neurodegenerative Disorders

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage