Biased Signaling in Physiology Pharmacology and Therapeutics

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  • Publisher : Elsevier
  • Release : 05 June 2014
  • ISBN : 9780124115071
  • Page : 316 pages
  • Rating : 4.5/5 from 103 voters

Biased Signaling in Physiology Pharmacology and Therapeutics Book PDF summary

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling

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Biased Signaling in Physiology, Pharmacology and Therapeutics

Biased Signaling in Physiology, Pharmacology and Therapeutics
  • Author : Brian J Arey
  • Publisher : Elsevier
  • Release Date : 2014-06-05
  • ISBN : 9780124115071
DOWNLOAD BOOKBiased Signaling in Physiology, Pharmacology and Therapeutics

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate

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  • Publisher : Academic Press
  • Release Date : 2019-09-11
  • ISBN : 9780128167281
DOWNLOAD BOOKGPCRs

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible

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  • Publisher : Springer Nature
  • Release Date : 2021-08-28
  • ISBN : 9783030681685
DOWNLOAD BOOKCalving Management and Newborn Calf Care

This comprehensive textbook provides detailed information on calving management in dairy and beef cattle. Enriched with diverse learning opportunities, it conveys the fundamentals of reproductive anatomy and physiology, parturition, birth complications and various obstetrical manoeuvres, as well as dam and calf care. In order to promote best practices in this specialized subject, the book covers all significant points from conception to calving and the perinatal period. Clear chapter structures, a wealth of illustrations and videos, obstetrical case studies, and question-and-answer

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  • Publisher : Elsevier
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  • ISBN : 9780124172067
DOWNLOAD BOOKPharmacology and Therapeutics of Constitutively Active Receptors

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  • ISBN : 9780123859525
DOWNLOAD BOOKPharmacology of G Protein Coupled Receptors

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DOWNLOAD BOOKNew Trends in Macromolecular and Supramolecular Chemistry for Biological Applications

This contributed volume applies the insights of supramolecular chemistry to biomedical applications such as ions/water transport through nano-scale channels, gene therapy, tissue engineering and drug delivery, to cite some of the major investigations.The challenge is to understand the mechanisms of transport through tissues particularly in the therapeutic treatment of a disease where the active drug must be delivered directly to diseased cells without affecting healthy cells. As a result, smaller quantities of active substances can be used to

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  • Release Date : 2017-08-18
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DOWNLOAD BOOKCannabinoid Pharmacology

Cannabinoid Pharmacology, Volume 80 is a new volume in the Advances in Pharmacology that presents reviews of recent breakthroughs. This volume aims to present current knowledge of the endogenous cannabinoid system, and looks at molecular, cellular, tissue and organismal effects of endogenous and exogenous cannabinoids. Topics of note in this new volume include Endocannabinoids and their congeners, Endocannabinoid turnover, Plant cannabinoids, Synthetic cannabinoids and ‘legal highs’, CB1 and CB2 cannabinoid receptors, Novel signaling modalities, Novel cannabinoid receptors, and Ion channel regulation

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  • ISBN : 9780128021958
DOWNLOAD BOOKChemokines

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  • Publisher : BoD – Books on Demand
  • Release Date : 2018-11-21
  • ISBN : 9781789845044
DOWNLOAD BOOKMelatonin

Melatonin, the pineal neurohormone, is a pleiotropic molecule acting in the center of the integrative molecular mechanisms of the organism, based on interconnections of the regulatory systems: neural, endocrine, immune, and genetic, conveying into the uniqueness of human architecture. This book provides a systematic and updated overview of melatonin biochemical mechanisms of action, pharmacological features, and clinical uses, clutching the subject with complete details of pharmaceutical formulations designed for different routes of administration and different health issues, aiming at optimal

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DOWNLOAD BOOKHandbook on Opium

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  • Publisher : Harvard University Press
  • Release Date : 2014-11-25
  • ISBN : 9780674967489
DOWNLOAD BOOKMolecular and Cellular Physiology of Neurons, Second Edition

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  • ISBN : 9780128137529
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