Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids

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  • Publisher : Woodhead Publishing
  • Release : 04 April 2017
  • ISBN : 9780081005637
  • Page : 256 pages
  • Rating : 4.5/5 from 103 voters

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids Book PDF summary

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field

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Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids
  • Author : Surendra Nimesh,Ramesh Chandra,Nidhi Gupta
  • Publisher : Woodhead Publishing
  • Release Date : 2017-04-04
  • ISBN : 9780081005637
DOWNLOAD BOOKAdvances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles

Nucleic Acid Nanotheranostics

Nucleic Acid Nanotheranostics
  • Author : Marco Filice,Jesús Ruiz-Cabello
  • Publisher : Elsevier
  • Release Date : 2019-02-26
  • ISBN : 9780128144718
DOWNLOAD BOOKNucleic Acid Nanotheranostics

Nucleic Acid Nanotheranostics: Biomedical Applications offers a comprehensive overview of improvements and new trends in fabrication of nanostructures as theranostic multifunctional carriers in gene therapy. With a strong focus on medical applications (comprising diagnosis, therapy and imaging), the book also examines gene therapy in an individual patient’s cells or tissues to treat genetic diseases. Sections cover Biomedical and Diagnostic applications of Nucleic Acids, Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery, and important considerations of nanomedicine. This book

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  • Publisher : Academic Press
  • Release Date : 2019-08-27
  • ISBN : 9780128197783
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Advances and Challenges in Nanomedicine
  • Author : Susan Hua,Sherry Y. Wu
  • Publisher : Frontiers Media SA
  • Release Date : 2019-02-28
  • ISBN : 9782889457458
DOWNLOAD BOOKAdvances and Challenges in Nanomedicine

Nanotechnology is a multidisciplinary field that is revolutionizing the way we detect and treat damage to the human body. Nanomedicine applies nanotechnology to highly specific medical interventions for the prevention, diagnosis, and treatment of diseases. They are increasingly being used to overcome biological barriers in the body to improve the way we deliver compounds to specific tissues and organs. In particular, nanomedicines have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and

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  • Publisher : John Wiley & Sons
  • Release Date : 2013-02-01
  • ISBN : 9781118635841
DOWNLOAD BOOKNanomedicine for Drug Delivery and Therapeutics

This book describes a broad area of nanomedicine which involves mainly applications, diseases, and diagnostics. The comprehensive coverage provides researchers, academics, and health specialists with a great tool, that includes techniques applicable to various uses.

Therapeutic Oligonucleotides

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  • Author : Jens Kurreck
  • Publisher : Royal Society of Chemistry
  • Release Date : 2008
  • ISBN : 9780854041169
DOWNLOAD BOOKTherapeutic Oligonucleotides

This book provides a compelling overall update on current status of RNA interference

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  • Publisher : Woodhead Publishing
  • Release Date : 2016-01-09
  • ISBN : 9780081005217
DOWNLOAD BOOKPolymers and Nanomaterials for Gene Therapy

Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials.

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  • ISBN : 9789815040388
DOWNLOAD BOOKMixed Polymeric Micelles for Osteosarcoma Therapy: Development and Characterization

Osteosarcoma is a rare bone tumor that has a high incidence amongchildren and young adults. Despite recent therapeutic developments, osteosarcomastill presents major hurdles to achieving successful results, mainly due to thepresence of multi-drug-resistant cells.This monograph primarily aims to provide information about the basicscience behind the treatment of osteosarcoma along with experimental resultsfor a novel formulation that overcomes multidrug resistance, and therefore, mayserve as a viable treatment option. The book starts with an updated and conciseguide to the pathophysiology of

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  • Publisher : CRC Press
  • Release Date : 2019-10-10
  • ISBN : 9780429521546
DOWNLOAD BOOKNanotechnology in Biology and Medicine

Nanotechnology in biology and medicine: Research advancements & future perspectives is focused to provide an interdisciplinary, integrative overview on the developments made in nanotechnology till date along with the ongoing trends and the future prospects. It presents the basics, fundamental results/current applications and latest achievements on nanobiotechnological researches worldwide scientific era. One of the major goals of this book is to highlight the multifaceted issues on or surrounding of nanotechnology on the basis of case studies, academic and theoretical articles,

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  • Publisher : William Andrew
  • Release Date : 2018-02-14
  • ISBN : 9780128136669
DOWNLOAD BOOKNanostructures for the Engineering of Cells, Tissues and Organs

Nanostructures for the Engineering of Cells: Tissues and Organs showcases recent advances in pharmaceutical nanotechnology, with particular emphasis on tissue engineering, organ and cell applications. The book provides an up-to-date overview of organ targeting and cell targeting using nanotechnology. In addition, tissue engineering applications, such as skin regeneration are also discussed. Written by a diverse range of international academics, this book is a valuable research resource for researchers working in the biomaterials, medical and pharmaceutical industries. Explains how nanomaterials regulate

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  • Publisher : Elsevier
  • Release Date : 2020-09-30
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DOWNLOAD BOOKNanotechnology Applications for Cancer Chemotherapy

Applications of Nanotechnology in Cancer Chemotherapy offers a complete and concise summary of nanotechnological interventions for cancer management. It highlights the basics of oncology, the cancer microenvironment, targets for active drug delivery, the underlying mechanisms and molecular pathways to enhance the drug delivery to the cancer site. The book discusses the principles of basic and innovative nanocarrier-based therapeutic approaches to modulate the progression of the disease. In addition, this book also explores the evolving targeting approaches specific to the cancer

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  • Publisher : Academic Press
  • Release Date : 2021-07-28
  • ISBN : 9780323859820
DOWNLOAD BOOKNano-Pharmacokinetics and Theranostics

Nano-Pharmacokinetics and Theranostics: Advancing Cancer Therapy addresses from a comprehensive and multidisciplinary approach the translational aspects and clinical perspectives of nano-pharmacokinetics using cancer as a model disease. Nano-pharmacokinetics is emerging as an important sub discipline of nanoscience and medical sciences because of the increasing safety issues of nanosystems on living organisms. This book reports the dynamics of nanosystems in living organisms for better understanding of nanotoxicity, pharmacology, biochemistry, physiology and medicine perspectives. It further examines current progress of state-of-the art

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  • Release Date : 2021-11-30
  • ISBN : 9781000375268
DOWNLOAD BOOKDrug Delivery with Targeted Nanoparticles

Nanotechnology has the potential to change every part of our lives. Today, nanotechnology-based products are used in many areas, and one of the most important areas is drug delivery. Nanoparticulate drug delivery systems not only provide controlled delivery of drugs and improved drug solubility but also improve drug efficiency and reduce side effects via targeting mechanisms. However, compared with conventional drug delivery systems, few nanoparticle-based products are on the market and almost all are nontargeted or only passively targeted systems.

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  • Publisher : MDPI
  • Release Date : 2020-12-07
  • ISBN : 9783039436750
DOWNLOAD BOOKSelected Papers from the 3rd European Congress on Imaging Infection and Inflammation

This Special Issue is a collection of selected papers from the 3rd European Congress on Imaging Infection and Inflammation (www.nuclearmedicinediscovery.org/events.asp) and results of consensus sessions by major experts in the field including Nuclear Medicine physicians, Radiologists, Clinicians and microbiologists. The Journal of Clinical Medicine (JCM) provides an opportunity to publish data that were presented and discussed at the meeting in Rome in December 2019. One of the extremely important missions of this meeting was to present the

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